AI Article Synopsis
- Trifluoromethoxylation is a tough reaction to carry out, but this research presents a new solution.
- By combining DMAP with 1,4-dinitro-trifluoromethoxybenzene (DNTFB), a stable trifluoromethoxide anion solution can be created.
- This stable solution enables S2 reactions without relying on costly silver additives, and the study also explores its properties and behavior.
Article Abstract
Despite recent advances, trifluoromethoxylation remains a challenging reaction. Here we describe an efficient trifluoromethoxylative substitution, using an inexpensive and easy-to-handle reagent. By mixing DMAP with a slight excess of 1,4-dinitro-trifluoromethoxybenzene (DNTFB), a stable solution of trifluoromethoxide anion is obtained and can be used to perform a S 2 reaction without any silver additives. A precise study of the properties and behavior of this unusual stable solution of CF O species is also performed.
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| http://dx.doi.org/10.1002/chem.202102809 | DOI Listing |
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