AI Article Synopsis
- Recent research indicates that paramagnetic rim lesions seen on MRI could be valuable biomarkers for diagnosing and understanding multiple sclerosis (MS).
- A systematic review and meta-analysis of 29 studies involving 1,230 patients found that the pooled prevalence of rim lesions was 9.8% at the lesion-level and 40.6% at the patient-level. Chronic active lesions were found in 12.0% and 64.8% of cases at the respective levels.
- There was notable variability in results between studies, especially related to MRI field strength and factors like age and disease duration, suggesting that these lesions are common but require careful assessment to understand their significance in MS.
Article Abstract
Background: Recent findings from several studies have shown that paramagnetic rim lesions identified using susceptibility-based MRI could represent potential diagnostic and prognostic biomarkers in multiple sclerosis (MS). Here, we perform a systematic review and meta-analysis of the existing literature to assess their pooled prevalence at lesion-level and patient-level.
Methods: Both database searching (PubMed and Embase) and handsearching were conducted to identify studies allowing the lesion-level and/or patient-level prevalence of rim lesions or chronic active lesions to be calculated. Pooled prevalence was estimated using the DerSimonian-Laird random-effects model. Subgroup analysis and meta-regression were performed to explore possible sources of heterogeneity. PROSPERO registration: CRD42020192282.
Results: 29 studies comprising 1230 patients were eligible for analysis. Meta-analysis estimated pooled prevalences of 9.8% (95% CI: 6.6-14.2) and 40.6% (95% CI: 26.2-56.8) for rim lesions at lesion-level and patient-level, respectively. Pooled lesion-level and patient-level prevalences for chronic active lesions were 12.0% (95% CI: 9.0-15.8) and 64.8% (95% CI: 54.3-74.0), respectively. Considerable heterogeneity was observed across studies (I2>75%). Subgroup analysis revealed a significant difference in patient-level prevalence between studies conducted at 3T and 7T (p = 0.0312). Meta-regression analyses also showed significant differences in lesion-level prevalence with respect to age (p = 0.0018, R2 = 0.20) and disease duration (p = 0.0018, R2 = 0.48). Other moderator analyses demonstrated no significant differences according to MRI sequence, gender and expanded disability status scale (EDSS).
Conclusion: In this study, we show that paramagnetic rim lesions may be present in an important proportion of MS patients, notwithstanding significant variation in their assessment across studies. In view of their possible clinical relevance, we believe that clear guidelines should be introduced to standardise their assessment across research centres to in turn facilitate future analyses.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425533 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256845 | PLOS |
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