AI Article Synopsis

  • Best practices for managing ileostomies include using immediate release (IR) medications and avoiding enteric coated and prokinetic agents.
  • A patient with an ileostomy showed poor response to extended-release (ER) potassium chloride, requiring significantly higher doses to improve potassium levels compared to IR potassium chloride.
  • Switching to IR potassium chloride resulted in a much lower dose needed for effective potassium replacement, indicating it may be a better option for patients with altered gastrointestinal tracts.

Article Abstract

Background: Best practices in the management of ileostomies include use of immediate release (IR) medications and elimination of enteric coated and prokinetic agents. Extended-release (ER) potassium chloride is designed for postpyloric release rather than colonic absorption and is postulated to be an appropriate option for potassium repletion in this patient subset.

Case: We present a patient with an ileostomy who received intravenous ER and IR oral potassium chloride supplementation following diverting loop ileostomy. Clinical responsiveness to ER potassium chloride was poor; 15 to 40 mEq was required to replace 0.1 mEq/L of potassium. However, upon transition to IR potassium chloride, only 6.67 mEq was required to replace 0.1 mEq/L of potassium.

Conclusions: Our experience in this case suggests that patients with surgical alterations to their gastrointestinal tracts who fail to have expected rises in serum potassium levels may benefit from early conversion to IR potassium chloride.

Download full-text PDF

Source
http://dx.doi.org/10.1097/WON.0000000000000801DOI Listing

Publication Analysis

Top Keywords

potassium chloride
24
potassium
9
extended-release potassium
8
meq required
8
required replace
8
replace meq/l
8
chloride
6
impaired absorption
4
absorption extended-release
4
chloride patient
4

Similar Publications

Counterintuitive DNA destabilization by monovalent salt at high concentrations due to overcharging.

Nat Commun

January 2025

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China.

Monovalent salts are generally believed to stabilize DNA duplex by weakening inter-strand electrostatic repulsion. Unexpectedly, our force-induced hairpin unzipping experiments and thermal melting experiments show that LiCl, NaCl, KCl, RbCl, and CsCl at concentrations beyond ~1 M destabilize DNA, RNA, and RNA-DNA duplexes. The two types of experiments yield different changes in free energy during melting, while the results that high concentration monovalent salts destabilize duplexes are common.

View Article and Find Full Text PDF

Ion channels play a crucial role in cardiac functions, and their activities exhibit dynamic changes during heart development. However, the precise function of ion channels in human heart development remains elusive. In this study, we utilized human embryonic stem cells (hESCs) as a model to mimic the process of human embryonic heart development.

View Article and Find Full Text PDF

Background And Aims: Salt substitute is considered an effective strategy to reduce sodium and increase potassium intake and thereby lower blood pressure in China, but its benefits and risks are uncertain in real-world data. This study is designed to compare the difference in the 1-year efficacy of salt substitute and salt restriction on urinary electrolytes and blood pressure.

Methods And Results: A total of 2,929 and 2,071 participants with the 24-h estimated urinary sodium excretion (eUNaE) above 2.

View Article and Find Full Text PDF

Heat sensation is mediated by specialized heat-sensitive neurons in the somatosensory system that innervates the skin. Previous studies revealed that noxious heat sensation is controlled by the sodium (Na)-activated potassium (K) channel Slick (Kcnt2), which is highly expressed in nociceptive Aδ-fibers. However, the mechanism by which Slick modulates heat sensation is poorly understood.

View Article and Find Full Text PDF

Bacterial infections causing necrotic enteritis and diarrhea pose a considerable economic loss to the animal industry. Using mannose oligosaccharides as competitive exclusion agents is an alternative method to antibiotic growth promoters; however, these materials are rapidly metabolized by gut microbiota, posing a challenge in sustaining their efficacy. The aim of this study was to identify an agglutination material that is effective against pathogens.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!