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Multielectrode Radiofrequency Balloon Catheter for Paroxysmal Atrial Fibrillation: Results From the Global, Multicenter, STELLAR Study.
J Cardiovasc Electrophysiol
December 2024
Mercy General Hospital and Dignity Health Heart and Vascular Institute, Sacramento, California, USA.
Introduction: The safety and efficacy of paroxysmal atrial fibrillation (PAF) ablation with the HELIOSTAR multielectrode radiofrequency (RF) balloon catheter have been demonstrated in European studies; data from elsewhere are lacking. This prospective, multicenter study conducted in the United States, Italy, and China investigated the safety and efficacy of pulmonary vein isolation (PVI) using HELIOSTAR in drug-refractory symptomatic PAF.
Methods: The primary effectiveness endpoint (PEE) was 12-month freedom from documented atrial fibrillation/atrial flutter/atrial tachycardia plus freedom from acute procedural failure, nonstudy catheter failure, repeat ablation failure, direct current cardioversion (DCCV), and Class I/III antiarrhythmic drug (AAD) failure.
Artificial intelligence-derived electrocardiographic aging and risk of atrial fibrillation: a multi-national study.
Eur Heart J
November 2024
Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Background And Aims: Artificial intelligence (AI) algorithms in 12-lead electrocardiogram (ECG) provides promising age prediction methods. This study investigated whether the discrepancy between ECG-derived AI-predicted age (AI-ECG age) and chronological age, termed electrocardiographic aging (ECG aging), is associated with atrial fibrillation (AF) risk.
Methods: An AI-ECG age prediction model was developed using a large-scale dataset (1 533 042 ECGs from 689 639 participants) and validated with six independent and multi-national datasets (737 133 ECGs from 330 794 participants).
SOX17-Associated Pulmonary Hypertension in Children: A Distinct Developmental and Clinical Syndrome.
J Pediatr
November 2024
Pediatric Heart Lung Center and Section of Pulmonary Medicine, Department of Pediatrics, University of Colorado Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO.
Objective: To characterize clinical, hemodynamic, imaging, and pathologic findings in children with pulmonary arterial hypertension (PAH) and variants in SRY-box transcription factor 17 (SOX17), a novel risk gene linked to heritable and congenital heart disease-associated PAH.
Study Design: We assembled a multi-institutional cohort of children with PAH and SOX17 variants enrolled in the Pediatric Pulmonary Hypertension Network (PPHNet) and other registries. Subjects were identified through exome and PAH gene panel sequencing.
Current Trends in the Treatment of Pediatric Hydrocephalus: A Narrative Review Centered on the Indications, Safety, Efficacy, and Long-Term Outcomes of Available Treatment Modalities.
Children (Basel)
October 2024
Neurosurgical Department, General Hospital of Athens 'Gennimatas', 10676 Athens, Greece.
Article Synopsis
- The pathophysiology of pediatric hydrocephalus remains unclear, and valve-based shunt systems have been the primary treatment option since the 1950s, transitioning from ventricular-atrial systems to peritoneal systems in the 1970s.
- The review highlights the comparison of valve types and emphasizes endoscopic third ventriculostomy (ETV) as the only surgical alternative today, which offers lower infection and re-operation rates, especially for children with previous shunt failures.
- It also identifies key predictive factors for ETV success and attempts to determine optimal treatment strategies for different patient subgroups, aiming to improve long-term outcomes for pediatric hydrocephalus patients.
Non-early catheter ablation vs drug therapy in atrial fibrillation: Results from the CABANA trial.
Heart Rhythm
November 2024
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Engineering Research Center of Medical Devices for Cardiovascular Diseases, Ministry of Education, National Clinical Research Center for Cardiovascular Diseases, Beijing, China. Electronic address:
Background: Early rhythm control reduces the risk of cardiovascular events in patients with atrial fibrillation (AF). Despite the superiority of catheter ablation in maintaining sinus rhythm, the knowledge gaps regarding the prognostic benefits of non-early (onset of AF ≥1 year) ablation remain.
Objective: The study aimed to describe outcomes of non-early AF in the CABANA trial.
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