AI Article Synopsis
- - The study examined heart failure (HF) classifications in primary care, focusing on prevalence and outcomes among different HF phenotypes in a group of 560 patients aged 45 and older.
- - Out of the participants, 9.1% were diagnosed with HF, with 21.6% having reduced ejection fraction (HFrEF), 19.6% having mid-range ejection fraction (HFmrEF), and 58.8% presenting preserved ejection fraction (HFpEF).
- - After a 5-year follow-up, patients with HFmrEF showed better health outcomes compared to those with HFpEF and HFrEF, indicating that HFmrEF has similar characteristics to HFpEF but
Article Abstract
Background: The classification of heart failure (HF) by phenotypes has a great relevance in clinical practice.
Objective: The study aimed to analyze the prevalence, clinical characteristics, and outcomes between HF phenotypes in the primary care setting.
Methods: This is an analysis of a cohort study including 560 individuals, aged ≥ 45 years, who were randomly selected in a primary care program. All participants underwent clinical evaluations, b-type natriuretic peptide (BNP) measurements, electrocardiogram, and echocardiography in a single day. HF with left ventricular ejection fraction (LVEF) < 40% was classified as HF with reduced ejection fraction (HFrEF), LVEF 40% to 49% as HF with mid-range ejection fraction (HFmrEF) and LVEF ≥ 50% as HF with preserved ejection fraction (HFpEF). After 5 years, the patients were reassessed as to the occurrence of the composite outcome of death from any cause or hospitalization for cardiovascular disease.
Results: Of the 560 patients included, 51 patients had HF (9.1%), 11 of whom had HFrEF (21.6%), 10 had HFmrEF (19.6%) and 30 had HFpEF (58.8%). HFmrEF was similar to HFpEF in BNP levels (p < 0.001), left ventricular mass index (p = 0.037), and left atrial volume index (p < 0.001). The HFmrEF phenotype was similar to HFrEF regarding coronary artery disease (p = 0.009). After 5 years, patients with HFmrEF had a better prognosis when compared to patients with HFpEF and HFrEF (p < 0.001).
Conclusion: The prevalence of ICFEI was similar to that observed in previous studies. ICFEI presented characteristics similar to ICFEP in this study. Our data show that ICFEi had a better prognosis compared to the other two phenotypes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395788 | PMC |
| http://dx.doi.org/10.36660/abc.20190912 | DOI Listing |
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