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Objectives: To describe common pulmonary vasodilators (PV), exposure timing, and characteristics associated to their use in very preterm (VP) infants.
Study Design: Observational study of VP infants discharged from U.S.
Oral sildenafil versus bosentan for treatment of persistent pulmonary hypertension of the newborn: a randomized controlled trial.
BMC Pediatr
November 2024
Department of Neonatology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, India.
Article Synopsis
- * Conducted on 36 neonates, the trial found that sildenafil led to a faster and more significant reduction of pulmonary arterial systolic pressure compared to bosentan within 48 hours.
- * The researchers suggest further large-scale studies to evaluate bosentan's efficacy and safety against other treatments for PPHN, especially in areas lacking access to advanced therapies like iNO.
An adenosinergic positive feedback loop extends pharmacological cardioprotection duration.
Br J Pharmacol
December 2024
Department of Pharmacology and Toxicology, University of Graz, Graz, Austria.
Background And Purpose: Adenosine receptor activation induces delayed, sustained cardioprotection against ischaemia-reperfusion (IR) injury (24-72 h), but the mechanisms underlying extended cardioprotection duration remain unresolved. We hypothesized that a positive feedback loop involving adenosine receptor-induced proteasomal degradation of adenosine kinase (ADK) and decreased myocardial adenosine metabolism extends the duration of cardioprotection.
Experimental Approach: Mice were administered an ADK inhibitor, ABT-702, to induce endogenous adenosine signalling.
Integrating computational and experimental chemical biology revealed variable anticancer activities of phosphodiesterase isoenzyme 5 inhibitors (PDE5i) in lung cancer.
RSC Med Chem
August 2024
Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan P.O. Box 130 Amman 11733 Jordan.
Phosphodiesterase 5 (PDE5), an enzyme responsible for catalyzing the degradation of cyclic guanosine monophosphate (cGMP), has been linked to the development of cancer. PDE5 inhibitors (PDE5i), such as sildenafil (Viagra) and tadalafil (Cialis), work by blocking the action of PDE5 and are used primarily as treatments for erectile dysfunction and arterial hypertension. Some studies suggested a potential link between PDE5i and increased cancer risk, while other studies showed preferable antitumor effects.
View Article and Find Full Text PDFIntra-Amniotic Sildenafil and Rosiglitazone Late in Gestation Ameliorate the Pulmonary Hypertension Phenotype in Congenital Diaphragmatic Hernia.
J Pediatr Surg
August 2024
Division of Pediatric Surgery, Department of Surgery, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224-1334, USA; Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:
Background: Pulmonary hypertension remains difficult to manage in congenital diaphragmatic hernia (CDH). Prenatal therapy may ameliorate postnatal pulmonary hypertension. We hypothesized that intra-amniotic (IA) injection of either sildenafil, a phosphodiesterase 5 inhibitor, or rosiglitazone, a PPAR-γ agonist, or both late in gestation would decrease the detrimental pulmonary vascular remodeling seen in CDH and improve peripheral pulmonary blood flow.
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