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Pediatric parenteral nutrition and hydroperoxide toxicity: Evaluation of the effectiveness of photoprotection medical devices.
Photochem Photobiol
September 2024
Nantes Université, CHU Nantes, Pharmacie, Nantes, France.
Article Synopsis
- Exposure to light during parenteral nutrition (PN) leads to the formation of harmful hydroperoxides (HPO), which can be particularly dangerous for pediatric patients.
- A study evaluated the effectiveness of using photoprotection devices, such as opaque syringes and overwraps, to minimize HPO formation when PN is exposed to light.
- Results showed that using opaque syringes reduced HPO by 14% and opaque overwraps by 40% after 420 minutes of light exposure, suggesting that photoprotection during PN administration is advisable, especially for vulnerable patients.
Syringe-dispensed omega-3 lipid injectable emulsions should be stored under airtight refrigeration: A proposal for the efficient supply of unapproved precious lipid resources.
JPEN J Parenter Enteral Nutr
November 2022
Working Group for Inflammatory Bowel Disease and Intestinal Failure Providing Supportive and Hearty Care (WISH), Kagoshima, Japan.
Background: Both fish-oil lipid injectable emulsion (FO-ILE) and mixed-oil lipid injectable emulsion (MO-ILE) are key components of parenteral nutrition and require importation into Japan, and they are easily oxidized after opening. Given the small daily volumes of these lipids dispensed in infants and children with intestinal failure (IF), the purpose of the study was to identify the optimal storage method.
Methods: Lipids were prepared in polypropylene syringes in the following manner: air-sealing and photoprotection, air-sealing only, photoprotection only, and uncovered.
Photoprotection of parenteral nutrition: an international perspective.
Nutr Clin Pract
October 2021
Biopharma Stability Testing Laboratory, BioCity Nottingham, Nottingham, UK.
Recommendations for photoprotection of parenteral nutrition for premature infants: An ASPEN position paper.
Nutr Clin Pract
October 2021
Fresenius Kabi USA, LLC, Lake Zurich, Illinois, USA.
Although crucial in improving health outcomes in the preterm infants, parenteral nutrition (PN) is not without risk, especially if handled improperly. A growing body of evidence suggests that components of PN admixtures, including lipid injectable emulsions (ILEs), are susceptible to degradation, including oxidation when exposed to light (ie, photo-oxidation), resulting in the production of reactive oxygen species. Infants, especially those born preterm, are considered more susceptible to consequences of oxidative stress than children and adults.
View Article and Find Full Text PDFThe Impact of Vitamin D on Skin Aging.
Int J Mol Sci
August 2021
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
The active metabolites of vitamin D (D) and lumisterol (L) exert a variety of antiaging and photoprotective effects on the skin. These are achieved through immunomodulation and include anti-inflammatory actions, regulation of keratinocytes proliferation, and differentiation programs to build the epidermal barrier necessary for maintaining skin homeostasis. In addition, they induce antioxidative responses, inhibit DNA damage and induce DNA repair mechanisms to attenuate premature skin aging and cancerogenesis.
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