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| http://dx.doi.org/10.1186/s12931-021-01831-8 | DOI Listing |
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Article Synopsis
- The study investigates the relationship between immune system genes and Alzheimer's disease (AD) by analyzing 370 genes with a sample of over 3,500 participants, including AD patients and cognitively normal controls.
- A significant association was found between the common variant MGMT rs147073440 and AD risk, while rare damaging variants in genes RAB37 and EPCAM were also linked to AD risk, although these results were nominally associated.
- The findings highlight the complex role of immune system-related genes in AD, suggesting both protective and harmful influences on the disease's progression.
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