A visible light mediated stereospecific C(sp)-H difluoroalkylation of ()-aldoximes to ()-difluoroalkylated ketoximes has been described. In this reaction, (hetero)-aromatic and aliphatic difluoroalkylated ketoximes could be obtained with the retention of the configuration of the starting aldoximes. A preliminary mechanism study showed that a difluoromethyl radical an SET pathway was involved.
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| http://dx.doi.org/10.1039/d1ob01401c | DOI Listing |
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