A robust elastic net-reconstruction method for x-ray luminescence computed tomography.

. X-ray luminescence computed tomography (XLCT) has played a crucial role in pre-clinical research and effective diagnosis of disease. However, due to the ill-posed of the XLCT inverse problem, the generalization of reconstruction methods and the selection of appropriate regularization parameters are still challenging in practical applications. In this research, an robust Elastic net-ℓℓreconstruction method is proposed aiming to the challenge.. Firstly, our approach consists of ℓand ℓregularization to enhance the sparsity and suppress the smoothness. Secondly, through optimal approximation of the optimization problem, double modification of Landweber algorithm is adopted to solve the Elastic net-ℓℓregulazation. Thirdly, drawing on the ideal of supervised learning, multi-parameter K-fold cross validation strategy is proposed to determin the optimal parameters adaptively.. To evaluate the performance of the Elastic net-ℓℓmethod, numerical simulations, phantom and in vivo experiments were conducted. In these experiments, the Elastic net-ℓℓmethod achieved the minimum reconstruction error (with smallest location error, fluorescent yield relative error, normalized root-mean-square error) and the best image reconstruction quality (with largest contrast-to-noise ratio and Dice similarity) among all methods. The results demonstrated that Elastic net-ℓℓcan obtain superior reconstruction performance in terms of location accuracy, dual source resolution, robustness and in vivo practicability.. It is believed that this study will further benefit preclinical applications with a view to provide a more reliable reference for the later researches on XLCT.