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[Diagnostics and treatment of autism spectrum disorder in adulthood].
Psychiatr Hung
January 2025
Semmelweis Egyetem ÁOK Pszichiátriai és Pszichoterápiás Klinika, Budapest, Hungary, E-mail:
Autism spectrum disorder is a neurodevelopmental condition with unique characteristics of perception and neurocognition that begins in childhood and persists into adulthood. It significantly affects social integration and adaptation, and is a great challenge in terms of psychological coping. Intensive genetic and neurobiological research is focused at understanding the brain underpinnings of autism, and it is also at the forefront of pharmacological development.
View Article and Find Full Text PDFPrecision medicine and patient outcomes in intensive care unit: Culture sensitivity, antibiotics, and APACHE score IV.
J Educ Health Promot
November 2024
Department of Pharmaceutics, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan.
Background: In the intensive care unit (ICU), complex medical conditions require specialized care; the threat of antibiotic resistance is significant due to frequent antibiotic use. This study investigates the pivotal role of culture sensitivity testing in shaping antibiotic prescription practices and patient outcomes in ICUs.
Materials And Methods: By using a prospective observational-analytical design, medical data from 640 patients at a Karachi hospital for one year in 2022 were utilized.
Advances and challenges in diagnosing and managing adult autoimmune enteropathy.
World J Gastroenterol
January 2025
Department of Surgery, University Hospital of Larissa, Larissa 41334, Greece.
Autoimmune enteropathy (AIE) is a rare immune mediated disorder primarily affecting children, characterized by chronic diarrhea, malabsorption, vomiting, weight loss and villous atrophy. It has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac disease. Initial diagnostic criteria for AIE include small bowel villous atrophy, lack of response to dietary restrictions, presence of anti-enterocyte antibodies, and predisposition to autoimmunity without severe immunodeficiency.
View Article and Find Full Text PDFThe pathogenesis and management of heatstroke and heatstroke-induced lung injury.
Burns Trauma
January 2025
Treatment Center for Traumatic Injuries, The Third Affiliated Hospital, Southern Medical University, No. 183, Zhongshan Avenue West, Tianhe District, Guangzhou, 510063, Guangdong, China.
In the past two decades, record-breaking heat waves have caused an increasing number of heat-related deaths, including heatstroke, globally. Heatstroke is a life-threatening systemic condition characterized by a core body temperature >40°C and the subsequent development of multiple organ dysfunction syndrome. Lung injury is a well-documented complication of heatstroke and is usually the secondary cause of patient death.
View Article and Find Full Text PDFBiodegradable copper-doped calcium phosphate nanoplatform enables tumor microenvironment modulations for amplified ferroptosis in cervical carcinoma treatment.
Int J Pharm X
June 2025
Department of Gynecology, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, PR China.
As a recently discovered form of regulated cell death, ferroptosis has attracted much attention in the field cancer therapy. However, achieving considerably enhanced efficacy is often restricted by the overexpression of endogenous glutathione (GSH) in tumor microenvironment (TME). In this work, we report a ferroptosis-inducing strategy of GSH depletion and reactive oxygen species (ROS) generation based on a biodegradable copper-doped calcium phosphate (CaP) with L-buthionine sulfoximine (BSO) loading (denoted as BSO@CuCaP-LOD, BCCL).
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