Two diarylheptanoid heterodimers, zosterabisphenones A () and B (), were isolated from the seagrass . They feature unprecedented catechol keto tautomers, stable because of steric constraints. Their structure elucidation was based on extensive low-temperature NMR studies and ECD and MS data, with the essential aid of DFT prediction of NMR and ECD spectra. Zosterabisphenone B () was selectively cytotoxic against the adenocarcinoma colon cancer cell line HCT116 with IC 3.6 ± 1.1 μM at 48 h.
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| http://dx.doi.org/10.1021/acs.orglett.1c02537 | DOI Listing |
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