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http://dx.doi.org/10.2340/00015555-3920 | DOI Listing |
Indian Dermatol Online J
September 2024
Department of Dermatology, BGS Global Institute of Medical Sciences, Bengaluru, Karnataka, India.
Clin Exp Dermatol
January 2025
Tricholab AB, Warsaw, Poland.
Background: The histological hallmark of male androgenetic alopecia (MAGA) is transformation of terminal follicles into miniaturized secondary-vellus follicles. As the volume of the dermal papilla determines the size of the hair bulb and hair fibre diameter, any treatment induced increase in fibre diameter could be used as a proxy for reversal of hair follicle miniaturization. While clinical trials with minoxidil topical solution in MAGA do not demonstrate increased fibre diameter, vellus-to-terminal reconversion is shown in a humanized mouse model treated with MXL.
View Article and Find Full Text PDFBiofouling
January 2025
Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India.
Bacteria possess hair-like projections on their surface termed pili. The primary function of a pilus is to enable bacterial cell attachment to the host. Since pili are associated with cell adhesion, they play a major role in bacterial colonization and infection.
View Article and Find Full Text PDFBr J Dermatol
January 2025
Pfizer Inc, Paris, France.
Biofabrication
July 2024
Department of Dermatology, Columbia University Irving Medical Center, New York, NY 10032, United States of America.
Human skin vasculature features a unique anatomy in close proximity to the skin appendages and acts as a gatekeeper for constitutive lymphocyte trafficking to the skin. Approximating such structural complexity and functionality in 3D skin models is an outstanding tissue engineering challenge. In this study, we leverage the capabilities of the digital-light-processing bioprinting to generate an anatomically-relevant and miniaturized 3D skin-on-a-chip (3D-SoC) model in the size of a 6 mm punch biopsy.
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