AI Article Synopsis
- SARS-CoV-2 uses the ACE2 receptor to infect various human tissues, with higher levels of ACE2 observed in patients with comorbidities linked to severe COVID-19.
- Patients with Barrett's esophagus (BE) exhibit increased ACE2 expression in BE tissues, potentially due to the lower pH associated with this condition.
- The study indicates that lower pH increases ACE2 expression and viral load in human monocytes and that prior use of proton pump inhibitors may significantly elevate the risk of death from COVID-19.
Article Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect a broad range of human tissues by using the host receptor angiotensin-converting enzyme 2 (ACE2). Individuals with comorbidities associated with severe COVID-19 display higher levels of in the lungs compared to those without comorbidities, and conditions such as cell stress, elevated glucose levels and hypoxia may also increase the expression of . Here, we showed that patients with Barrett's esophagus (BE) have a higher expression of in BE tissues compared to normal squamous esophagus, and that the lower pH associated with BE may drive this increase in expression. Human primary monocytes cultured in reduced pH displayed increased expression and higher viral load upon SARS-CoV-2 infection. We also showed in two independent cohorts of 1,357 COVID-19 patients that previous use of proton pump inhibitors is associated with 2- to 3-fold higher risk of death compared to those not using the drugs. Our work suggests that pH has a great influence on SARS-CoV-2 Infection and COVID-19 severity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417536 | PMC |
| http://dx.doi.org/10.3389/fmed.2021.637885 | DOI Listing |
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