Comparative genomic analysis reveals metabolic flexibility of Woesearchaeota.

Nat Commun

Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen, China.

Published: September 2021

AI Article Synopsis

  • The archaeal phylum Woesearchaeota, part of the DPANN superphylum, consists of diverse microorganisms whose biology remains largely unstudied due to a scarcity of cultured isolates.
  • Current research involves analyzing 16S rRNA gene sequences and metagenome-assembled genomes to explore the global distribution, ecological preferences, and possible metabolic abilities of these organisms.
  • Phylogenomic findings classify Woesearchaeota into ten subgroups, with most expected to lead a symbiotic lifestyle, while subgroup J may live independently, and their genomes suggest potential metabolic roles as anaerobic fermentative heterotrophs.

Article Abstract

The archaeal phylum Woesearchaeota, within the DPANN superphylum, includes phylogenetically diverse microorganisms that inhabit various environments. Their biology is poorly understood due to the lack of cultured isolates. Here, we analyze datasets of Woesearchaeota 16S rRNA gene sequences and metagenome-assembled genomes to infer global distribution patterns, ecological preferences and metabolic capabilities. Phylogenomic analyses indicate that the phylum can be classified into ten subgroups, termed A-J. While a symbiotic lifestyle is predicted for most, some members of subgroup J might be host-independent. The genomes of several Woesearchaeota, including subgroup J, encode putative [FeFe] hydrogenases (known to be important for fermentation in other organisms), suggesting that these archaea might be anaerobic fermentative heterotrophs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421398PMC
http://dx.doi.org/10.1038/s41467-021-25565-9DOI Listing

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