AI Article Synopsis
- People living with HIV (PLWH) continue to experience high rates of lymphoma-related morbidity and mortality, prompting this study in a Chilean public hospital.
- The study analyzed data from 84 PLWH diagnosed with different types of lymphoma between 2010 and 2017 and compared their survival rates to a previous cohort from 1992 to 2008.
- Overall survival improved in this more recent cohort, particularly for patients with diffuse large B-cell lymphoma (DLBCL), largely attributed to better access to antiretroviral therapy, despite no significant changes in chemotherapy treatments.
Article Abstract
Introduction: People living with human immunodeficiency virus (PLWH) still face high morbidity and mortality resulting from lymphoma.
Aim: To describe a population of PLWH and lymphoma in a Chilean public hospital and compare the overall survival (OS) with a previously reported cohort from the same institution.
Methods: Retrospective single-center cohort study. All the patients diagnosed between 2010 and 2017 were included. Demographic and clinical variables were obtained from medical records. The overall survival (OS) was estimated in treated patients from diagnosis until death or October 2020. The OS was then compared with a cohort of patients diagnosed between 1992 and 2008.
Main Results: Eighty-four patients were included. The most common histological types were Burkitt´s lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), Hodgkin´s lymphoma (HL) and plasmablastic lymphoma (PBL) at 31%, 27%, 21% and 14%, respectively. The three-year OS for the whole cohort of BL, DLBCL, HL and PBL was 58.9%, 65.2%, 47.4%, 76.4% and 50%, respectively. Compared to the cohort of 1992 to 2008, a global increase in the OS was found after excluding HL and adjusting for age and clinical stage (HR 0.38, p = 0.002). However, when the main types were analyzed individually, the increase in the OS was statistically significant only in DLBCL (HR 0.29, p = 0.007). Most patients with DLBCL received CHOP chemotherapy, as in the previous cohort.
Conclusion: The OS has improved in this population, despite no major changes in chemotherapy regimens, mainly due to the universal access to antiretroviral therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605900 | PMC |
| http://dx.doi.org/10.1016/j.htct.2021.06.007 | DOI Listing |
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