Background: Facial cooling (FC) is effective in improving endurance exercise performance in hot environments. In this study, we evaluated the impact of intermittent short-lasting FC on the ratings of perceived exertion (RPE) during exercise.
Methods: Ten healthy men performed 40 continuous minutes of ergometric cycle exercise at 65% of the peak heart rate in a climatic chamber controlled at an ambient temperature of 35 °C and a relative humidity of 50%. In the control (CONT) trial, the participants performed the exercise without FC. In two cooling trials, each participant underwent 10 s of FC at 2- (FC2) and 4-min (FC4) intervals while continuing to exercise. FC was achieved by applying two soft-gel packs (cooled to 0 °C) directly and bilaterally on the forehead, eyes, and cheeks. In another cooling trial, 10 s of FC was performed at 2-min intervals using two soft-gel packs cooled to 20 °C (FC2-20).
Results: The RPE values in the FC4 trial were significantly lower than those in the CONT trial at 20 min (FC4, 11.6 ± 2.2 points; CONT, 14.2 ± 1.3 points; P < 0.01). Further, significant differences in the RPE values were observed between the FC4 and CONT trials at 5-15 min and 25-40 min (P < 0.05). RPE values were also significantly lower in the FC2 trial than in the CONT trial (5-40 min). Although the RPE values in the FC2-20 trial were significantly lower (5-10 min; 15-20 min) than those in the CONT trial, there were no significant differences in the RPE between the FC2-20 and CONT trials at 25-40 min. At 35 min, the RPE values were significantly higher in the FC2-20 trial than in the FC2 trial (P < 0.05).
Conclusion: Intermittent short-lasting FC was associated with a decrease in RPE, with shorter intervals and lower temperatures eliciting greater attenuation of increase in the RPE.
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http://dx.doi.org/10.1186/s40101-021-00262-0 | DOI Listing |
BMC Biol
January 2025
Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Background: Uveal melanoma (UM) is the most common intraocular tumor in adults, arises either de novo from normal choroidal melanocytes (NCMs) or from pre-existing nevi that stem from NCMs and are thought to harbor UM-initiating mutations, most commonly in GNAQ or GNA11. However, there are no commercially available NCM cell lines, nor is there a detailed protocol for developing an oncogene-mutated CM line (MutCM) to study UM development. This study aimed to establish and characterize premalignant CM models from human donor eyes to recapitulate the cell populations at the origin of UM.
View Article and Find Full Text PDFOphthalmology
January 2025
University of Bordeaux, INSERM, BPH, U1219, F-33000 Bordeaux, France; FRCRnet, F-CRIN network, France.
Purpose: We assessed the associations of macular layer thicknesses, measured using spectral-domain OCT (SD-OCT), with incident age-related macular degeneration (AMD) and AMD polygenic risk scores (PRS).
Design: Population-based cohort study PARTICIPANTS: 653 participants of the Alienor study, with biennial eye imaging from 2009 to 2024.
Methods: Macular layer thicknesses of eight distinct layers and three compound layers were automatically segmented based on SD-OCT imaging of the macula.
Int J Mol Med
March 2025
Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
Retinal pigment epithelial (RPE) cells undergoing epithelial‑mesenchymal transition (EMT) are a key factor in promoting the progression of subretinal fibrosis. The klotho protein and gene exert anti‑fibrotic effects in multiple fibrotic diseases. However, the mechanisms involved in the role of klotho are unclear in subretinal fibrosis.
View Article and Find Full Text PDFJ Strength Cond Res
January 2025
School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.
Cowley, N, Nicholson, V, Timmins, R, Munteanu, G, Wood, T, García-Ramos, A, Owen, C, and Weakley, J. The effects of percentage-based, rating of perceived exertion, repetitions in reserve, and velocity-based training on performance and fatigue responses. J Strength Cond Res XX(X): 000-000, 2024-This study assessed the effects of percentage-based training (%1RM), rating of perceived exertion (RPE), repetitions in reserve (RIR), and velocity-based training (VBT) on (a) acute kinematic outputs, perceptions of effort, and changes in neuromuscular function during resistance training; and (b) neuromuscular fatigue and perceptions of soreness 24 hours after exercise.
View Article and Find Full Text PDFJ Sports Med Phys Fitness
January 2025
INSERM UMR1093-CAPS, University of Bourgogne, University of Franche-Comté of Sport Sciences, Dijon, France.
Background: Highly trained academy soccer practitioners usually implement an aerobic-oriented session followed by a speed-oriented session during the first and second heavy load session of a training week, respectively. This study aimed to investigate if the order of these physical training sessions would influence the external training loads and the subsequent readiness level on match day.
Methods: Twenty-five highly trained academy soccer players (12 U17 and 13 U19) participated in two experimental weeks randomly presented.
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