Biological neurons have adaptive nature and perform complex computations involving the filtering of redundant information. However, most common neural cell models, including biologically plausible, such as Hodgkin-Huxley or Izhikevich, do not possess predictive dynamics on a single-cell level. Moreover, the modern rules of synaptic plasticity or interconnections weights adaptation also do not provide grounding for the ability of neurons to adapt to the ever-changing input signal intensity. While natural neuron synaptic growth is precisely controlled and restricted by protein supply and recycling, weight correction rules such as widely used STDP are efficiently unlimited in change rate and scale. The present article introduces new mechanics of interconnection between neuron firing rate homeostasis and weight change through STDP growth bounded by abstract protein reserve, controlled by the intracellular optimization algorithm. We show how these cellular dynamics help neurons filter out the intense noise signals to help neurons keep a stable firing rate. We also examine that such filtering does not affect the ability of neurons to recognize the correlated inputs in unsupervised mode. Such an approach might be used in the machine learning domain to improve the robustness of AI systems.
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http://dx.doi.org/10.1016/j.neunet.2021.08.016 | DOI Listing |
Eur J Neurosci
January 2025
Faculty of Medicine, Collegium Medicum, Mazovian Academy in Plock, Plock, Poland.
Chronic migraine (CM) is the ultimate and most burdensome form of the transformation from episodic migraine (EM), called chronification. The mechanism behind migraine chronification is poorly known and difficult to explore as CM has the same spectrum of pathogenesis as EM and the EM-CM transition is bidirectional. Central sensitization (CS) is a key phenomenon in migraine: its mechanisms include disturbed neural plasticity, which is the ability of the nervous system to adapt to endo- and exogenous changes.
View Article and Find Full Text PDFJ Fungi (Basel)
December 2024
Department of Chemical Engineering, Biotechnology, and Materials, Centre for Biotechnology and Bioengineering (CeBiB), University of Chile, Beauchef 851, Santiago 8370456, Chile.
Natural compounds derived from microorganisms, especially those with antioxidant and anticancer properties, are gaining attention for their potential applications in biomedical, cosmetic, and food industries. Marine fungi, such as , are particularly promising due to their ability to produce bioactive metabolites through the degradation of marine algal polysaccharides. This study investigates the metabolic diversity of grown on different carbon sources: glucose, spp.
View Article and Find Full Text PDFBiomimetics (Basel)
January 2025
Beijing Institute of Technology, Beijing 100081, China.
A future unmanned system needs the ability to perceive, decide and control in an open dynamic environment. In order to fulfill this requirement, it needs to construct a method with a universal environmental perception ability. Moreover, this perceptual process needs to be interpretable and understandable, so that future interactions between unmanned systems and humans can be unimpeded.
View Article and Find Full Text PDFHistol Histopathol
January 2025
Department of Neurology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang Jiangsu, PR China.
Parkinson's disease (PD) is a limb movement disorder caused by the degeneration of brain neurons and seriously affects the quality of life of the elderly. However, the current drugs are symptomatic treatments that cannot prevent or delay the development of the disease. Targeted therapy for pathogenesis may be the direction of development in the future.
View Article and Find Full Text PDFBioact Mater
April 2025
Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.
The mammalian brain has an extremely limited ability to regenerate lost neurons and to recover function following ischemic stroke. A biomaterial strategy of slowly-releasing various regeneration-promoting factors to activate endogenous neurogenesis represents a safe and practical neuronal replacement therapy. In this study, basic fibroblast growth factor (bFGF)-Chitosan gel is injected into the stroke cavity.
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