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http://dx.doi.org/10.1016/j.phrs.2021.105872 | DOI Listing |
Sci Rep
January 2025
Departamento Biología Experimental, Universidad de Jaén, Paraje Las Lagunillas S/N E23071, Jaén, Spain.
In this study, we investigate the G2 checkpoint activated by chromosome entanglements, the so-called Decatenation Checkpoint (DC), which can be activated by TOP2A catalytic inhibition. Specifically, we focus on the spontaneous ability of cells to bypass or override this checkpoint, referred to as checkpoint adaptation. Some factors involved in adapting to this checkpoint are p53 and MCPH1.
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January 2025
Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration (FDA), Jefferson, AR, U.S.A.
Infections associated with urinary catheters are often caused by biofilms composed of various bacterial species that form on the catheters' surfaces. In this study, we investigated the intricate interplay between Escherichia coli and Enterococcus faecalis during biofilm formation on urinary catheter segments using a dual-species culture model. We analyzed biofilm formation and global proteomic profiles to understand how these bacteria interact and adapt within a shared environment.
View Article and Find Full Text PDFExp Neurol
January 2025
Thomas Jefferson University, Thomas Jefferson University, Department of Physical Medicine and Rehabilitation, Philadelphia, PA, USA.
Pre-clinical research is intended to inform clinical research, however, communication between these researchers is lacking. A better understanding of what can be learned from animal and human models and what cannot, is essential. This includes a better understanding of where underlying constructs in outcome measures in rodents and humans align and where they diverge to improve dialogue between human and animal researchers.
View Article and Find Full Text PDFDiscov Ment Health
January 2025
Faculty of Psychology, Ho Chi Minh City University of Education, 280 An Duong Vuong, Ward 4, District 5, Ho Chi Minh City, Vietnam.
This study focuses on filial piety, a fundamental psychological factor in Vietnam and its relationship with religiosity and attitudes toward abortion. Drawing on data from 656 participants, the research employed the Partial Least Squares-Structural Equation Modeling (PLS-SEM) method and identified significant differences in intrinsic religiosity (IR) based on various forms of cohabitation with parents. Furthermore, the findings revealed a positive association between age and religiosity.
View Article and Find Full Text PDFACS Chem Neurosci
January 2025
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
The deposition of amyloid-β (Aβ) aggregates and metal ions within senile plaques is a hallmark of Alzheimer's disease (AD). Among the modifications observed in Aβ peptides, -terminal truncation at Phe4, yielding Aβ, is highly prevalent in AD-affected brains and significantly alters Aβ's metal-binding and aggregation profiles. Despite the abundance of Zn(II) in senile plaques, its impact on the aggregation and toxicity of Aβ remains unexplored.
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