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Colorectal cancer screening using a multi-locus blood-based assay targeting circulating tumor DNA methylation: a cross-sectional study in an average-risk population.
BMC Med
November 2024
National Center for Chronic and Non-Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing, 100050, China.
Background: Effective screening for colorectal cancer (CRC) enables earlier diagnosis and intervention to improve patient survival.
Methods: In this study, we prospectively conducted a blood-based CRC screening program for community residents in Hanjiang District, Yangzhou City, and evaluated the screening efficacy of a blood-based multi-locus DNA methylation assay (ColonAiQ). The ColonAiQ-positive rate and colonoscopy participation rate of the population, detection rate of intestinal lesions, and positive predictive value (PPV) of CRC and advanced adenoma (AA) were calculated, and the associated factors were explored.
Early detection and prognosis evaluation for hepatocellular carcinoma by circulating tumour DNA methylation: A multicentre cohort study.
Clin Transl Med
May 2024
Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai, China.
Article Synopsis
- Scientists are working on a blood test called HepaAiQ to help find liver cancer (HCC) early, which can help patients live longer.
- They tested this blood test on a lot of people, comparing HCC patients to healthy people and those with other liver issues.
- The blood test showed it could correctly identify HCC cases most of the time and might help doctors predict patient outcomes after treatment.
A Multilocus Blood-Based Assay Targeting Circulating Tumor DNA Methylation Enables Early Detection and Early Relapse Prediction of Colorectal Cancer.
Gastroenterology
December 2021
Singlera Genomics (Shanghai) Ltd, Shanghai, China.
Improvements and inter-laboratory implementation and optimization of blood-based single-locus age prediction models using DNA methylation of the ELOVL2 promoter.
Sci Rep
September 2020
Laboratory for Genomics, Foundation Jean Dausset-CEPH, 75010, Paris, France.
Several blood-based age prediction models have been developed using less than a dozen to more than a hundred DNA methylation biomarkers. Only one model (Z-P1) based on pyrosequencing has been developed using DNA methylation of a single locus located in the ELOVL2 promoter, which is considered as one of the best age-prediction biomarker. Although multi-locus models generally present better performances compared to the single-locus model, they require more DNA and present more inter-laboratory variations impacting the predictions.
View Article and Find Full Text PDFCandidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults.
Am J Geriatr Psychiatry
October 2014
Sam and Rose Stein Institute for Research on Aging, and Department of Psychiatry, University of California, San Diego, CA. Electronic address:
Objective: Optimism and resilience promote health and well-being in older adults, and previous reports suggest that these traits are heritable. We examined the association of selected single-nucleotide polymorphisms (SNPs) with optimism and resilience in older adults.
Design: Candidate gene association study that was a follow-on at the University of California, San Diego, sites of two NIH-funded multi-site longitudinal investigations: Women's Health Initiative (WHI) and SELenium and vitamin E Cancer prevention Trial (SELECT).
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