AI Article Synopsis
- 25-Hydroxycholecalciferol (25-HCC) levels were studied in 172 healthy individuals, divided by age groups: children, younger adults (under 50), and older adults (over 50).
- Seasonal variations showed that children consistently had higher 25-HCC levels compared to the other groups, particularly during periods of maximum solar irradiation.
- The study highlights a negative correlation between age and 25-HCC levels, indicating that both age and seasonal sunlight exposure significantly affect vitamin D metabolism.
Article Abstract
The 25-hydroxycholecalciferol (25-HCC) levels have been quantified in 172 normal controls. Three groups were considered: children (0-12 years), younger than 50 year-old adults and older than 50 year-old adults. In order to evaluate the seasonal variations in this metabolite their levels throughout the year were quantified. A negative correlationship was observed between age and 25-HCC levels. Grouping the levels according to maximum and minimum solar irradiation, the children's group showed higher values than the other groups in both seasons, while younger group (under 50 years of age) showed higher levels than the older group only in maximum solar irradiation. The children's and younger people's groups showed significant differences in the 25-HCC levels between the period of maximum and minimum solar irradiation which did not occur in the older group. In our geographic area, age and seasons of the year are factors that may influence 25-HCC levels. Therefore knowledge of these factors is basic for understanding correctly these metabolite levels.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Mesoderm/mesenchyme homeobox l may promote tumor progression in human hepatocellular carcinoma.
Adv Clin Exp Med
December 2024
Department of Infectious Diseases, The 980th Hospital of People's Liberation Army (PLA) Joint Logistics Support Force, Shijiazhuang, China.
Background: The clinical response rate for molecularly targeted medications is limited despite significant advancements in molecularly targeted therapy for hepatocellular carcinoma (HCC). Therefore, it is necessary to find new and robust therapeutic targets for the treatment of HCC. Recent research has shown that mesoderm/mesenchyme homeobox gene 1 (Meox1) is closely associated with cancer progression.
View Article and Find Full Text PDFEstimating Vitamin D threshold for the Indian population: Delving into the actual disease burden.
Med J Armed Forces India
December 2023
Professor (Aerospace Medicine), Institute of Aerospace Medicine, Vimanpura, Bengaluru, India.
Background: Based on the current guidelines in practice, a vast majority of the healthy Indian population is vitamin D deficient. Since the serum 25 hydroxycholecalciferol (25HCC) levels are affected by race and skin pigmentation, the normal range of vitamin D may differ in the Indians compared to the Western population. This study attempted to determine a population-specific threshold for 25 HCC levels associated with adequate bone health and calcium and phosphate homeostasis in healthy Indians.
View Article and Find Full Text PDFComprehensive analysis of prognostic value and immune infiltration of IAPs family in hepatocellular carcinoma.
J Cancer
September 2023
Departments of Ultrasound Imaging, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality rates. The inhibitors of apoptosis (IAP) family act as oncogenes in various tumor types; however, their functions in HCC remain unclear. Here, we used integrated bioinformatics analysis and experimental verification to assess the expression and the prognostic and clinical value of the IAP family in HCC.
View Article and Find Full Text PDFCirculating Cell-Free DNA Profiling Predicts the Therapeutic Outcome in Advanced Hepatocellular Carcinoma Patients Treated with Combination Immunotherapy.
Cancers (Basel)
July 2022
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Article Synopsis
- Combination immunotherapy using anti-PD-L1 and anti-VEGF antibodies is the standard treatment for patients with unresectable HCC, but it doesn’t benefit all patients equally.
- A study involving 85 HCC patients showed that high levels of cell-free DNA (cfDNA) in the blood correlate with poorer treatment responses and shorter survival outcomes.
- Specific mutations in ctDNA, particularly in the TERT gene, can indicate worse prognosis and may help doctors assess treatment effectiveness for patients receiving this therapy.
Ablation Zone Involution of Liver Tumors Is Faster in Patients Treated with Irreversible Electroporation Than Microwave Ablation.
Medicina (Kaunas)
August 2021
Department of Mechanical & Industrial Engineering, University of Massachusetts, Amherst, MA 01002, USA.
: To compare ablation zone involution following microwave ablation (MWA) or irreversible electroporation (IRE) of liver tumors. : MWA or IRE performed for colorectal cancer liver metastasis (CRLM) or hepatocellular carcinoma (HCC) during January 2011 to December 2015 were analyzed. Patients with a tumoral response on 1-year follow-up computed tomography (CT) were included.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!