The hypoxia-hypoxia-inducible factor (HIF)-1α-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen-ventilated COVID-19 patients by exacerbating inflammatory lung damage. Restoration of this pathway with hypoxia-adenosinergic drugs may improve outcomes in these patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742736 | PMC |
| http://dx.doi.org/10.1152/physiol.00010.2021 | DOI Listing |
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