Purpose: To describe a case of acute macular neuroretinopathy (AMN) in a patient immediately following administration of the Pfizer-BioNTech COVID-19 vaccine.
Observations: The patient complained of paracentral scotoma supported by paracentral visual field loss on multiple Humphrey visual fields that corresponded to outer retinal pathology on optical coherence tomography. The patient's symptoms resolved without treatment.
Conclusions And Importance: We conclude that the clinical testing demonstrated findings consistent with AMN. AMN may be an exceedingly rare adverse ocular effect of a novel vaccine and likely only in the setting of multiple other risk factors. Despite this, we strongly recommend vaccination against COVID-19.
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http://dx.doi.org/10.1016/j.ajoc.2021.101200 | DOI Listing |
Sci Rep
December 2024
Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
We used machine learning to investigate the residual visual field (VF) deficits and macula retinal ganglion cell (RGC) thickness loss patterns in recovered optic neuritis (ON). We applied archetypal analysis (AA) to 377 same-day pairings of 10-2 VF and optical coherence tomography (OCT) macula images from 93 ON eyes and 70 normal fellow eyes ≥ 90 days after acute ON. We correlated archetype (AT) weights (total weight = 100%) of VFs and total retinal thickness (TRT), inner retinal thickness (IRT), and macular ganglion cell-inner plexiform layer (GCIPL) thickness.
View Article and Find Full Text PDFIndian J Ophthalmol
January 2025
Uveitis and Retina Services, L V Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India.
Purpose: To study clinical features, anatomical and visual outcomes in eyes having rhegmatogenous retinal detachment (RD) as the presenting feature of acute retinal necrosis (ARN).
Materials And Methods: We conducted a retrospective cohort study of patients with ARN (active/healed) and concomitant RD at the presenting visit.
Results: The median age of patients was 36 years, with a male preponderance (9:1).
Leuk Lymphoma
November 2024
Department of Medicine, Hematology and Stem Cell Transplant, University of Udine, Udine, Italy.
PNAS Nexus
December 2024
Department of Ophthalmology and Stein Eye Institute, University of California, Los Angeles, CA 90095, USA.
As the SARS-CoV-2 coronavirus continues to evolve and infect the global population, many individuals are likely to suffer from post-acute sequelae of SARS-CoV-2 infection (PASC). Manifestations of PASC include vision symptoms, but little is known about the ability of SARS-CoV-2 to infect and impact the retinal cells. Here, we demonstrate that SARS-CoV-2 can infect and perturb the retinal pigment epithelium (RPE) in vivo, after intranasal inoculation of a transgenic mouse model of SARS-CoV-2 infection, and in cell culture.
View Article and Find Full Text PDFFuture Microbiol
December 2024
Department of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
usually presents with erythrasma, a macular rash, but rarely it can cause extracutaneous infections such as endocarditis, peritonitis, pyelonephritis, and catheter-related bloodstream infections. Here, we present the first case of septic arthritis caused by and a literature review of invasive infections. The diagnosis was confirmed by the patient's clinical findings and microbiological examination of the joint fluid.
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