The resting membrane potential of innervated and denervated rat diaphragm muscle fibres was studied at different concentrations of Cl-, K+ and Na+ in the external solution and following the furosemide treatment. The Cl- equilibrium potential (ECl) and resting potential are equal in innervated fibres while denervation shifts the ECl value in the positive direction when compared with the resting potential value. The postdenervation depolarization is delayed in furosemide-treated muscles. It is concluded that neurotrophic control disturbance leads to activation of furosemide-sensitive Cl-influx system, which causes elevation of the intracellular concentration of chloride ions and muscle membrane depolarization.
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