Costa Rica has long been a country of special interest in the Americas and in global health because of its good health. The United Nations Development Programme ranks countries according to their level of human development based on life expectancy, education and national income. Although Costa Rica is ranked at 63 and classified as 'High', in terms of health it belongs in the 'Very High' group. In 2018 mean life expectancy for the 'Very High' countries was 79.5, while in Costa Rica it was 80. In 2018, under five mortality was 8.8/1000 live births, lower than countries ranked in the 'Very High' human development group. Expected years of schooling in Costa Rica is 15.4, closer to the average, 16.4 years, of the 'Very High' human development group than the average of the 'High' group. The country is much healthier than would be predicted by its national income; rather, other features of society's development are likely to have played a key role in the development of good health. These include (i) the decision to cease investment in national defence, which freed up money to invest in health, education and the welfare of the population; (ii) the decision to create a universal health system financed by the State, employers and workers in the 1940s; and (iii) the educational system, that generated opportunities to lift important sectors of the population out of poverty, allowing them to have basic sanitary conditions that increase their possibilities to live longer and in better conditions. Despite these advances, inequalities in terms of income and social conditions persist, presenting challenges in the field of health, particularly for lower-income populations and those of African and indigenous descent. These inequalities must be addressed using decisions based on scientific evidence, a greater use of disaggregated data to reveal progress in addressing these inequalities, and with a broader articulation of the health sector with policies that act on the social determinants of health.
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http://dx.doi.org/10.26633/RPSP.2021.101 | DOI Listing |
Pharmaceutics
January 2025
Programa de Posgrado en Odontología, Universidad de Costa Rica, Ciudad Universitaria Rodrigo Facio, San Jose 11501-2060, Costa Rica.
Objectives: This study aimed to synthesize polylactic acid (PLA) nanofibrillar scaffolds loaded with ibuprofen (IBU) using electrospinning (ES) and air-jet spinning (AJS). The scaffolds were evaluated for their physicochemical properties, drug release profiles, and biocompatibility to assess their potential for local analgesic applications.
Methods: Solutions of 10% (/) PLA combined with IBU at concentrations of 10%, 20%, and 30% were processed into nanofibrillar membranes using ES and AJS.
Pharmaceutics
January 2025
Pharmacy, Pharmaceutical Technology and Physico-Chemical Department, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
This study explores the development and characterization of lyophilized chondroitin sulfate (CHON)-loaded solid lipid nanoparticles (SLN) as an innovative platform for advanced drug delivery. Solid lipid nanoparticles are increasingly recognized for their biocompatibility, their ability to encapsulate diverse compounds, their capacity to enhance drug stability, their bioavailability, and their therapeutic efficacy. CHON, a naturally occurring glycosaminoglycan with anti-inflammatory and regenerative properties, was integrated into SLN formulations using the hot microemulsion technique.
View Article and Find Full Text PDFPlants (Basel)
January 2025
Escuela de Ingeniería en Agronomía, Campus Tecnológico Local San Carlos, Tecnológico de Costa Rica, Alajuela 22321001, Costa Rica.
The role of a plant root system in resource acquisition is relevant to confront drought events caused by climate change. Accordingly, nursery practices like phosphorous (P) fertilization and root pruning have been shown to modify root architecture; however, their combined benefits require further investigation in Mediterranean species. We evaluated the effect of applied P concentrations (0, 15, 60, and 120 mg L P) with or without chemical (copper) root pruning (WCu, WoCu, respectively) in and on morpho-physiological and root architecture traits.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Medical Specialties I, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Purpose: is the main etiologic agent implicated in primary amoebic meningoencephalitis (PAM). It is also known as the brain-eating amoeba because of the severe brain inflammation following infection, with a survival rate of about 5%. This review aims to identify infections and evaluate patients' progression.
View Article and Find Full Text PDFRespir Res
January 2025
Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Background: MicroRNAs (miRNAs) are crucial post-transcriptional regulators involved in inflammatory diseases, such as asthma. Poor lung function and airflow issues in childhood are linked to the development of chronic obstructive pulmonary disease (COPD) in adulthood.
Methods: We analyzed small RNA-Seq data from 365 peripheral whole blood samples from the Genetics of Asthma in Costa Rica Study (GACRS) for association with airflow levels measured by FEV1/FVC.
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