Here, we used Bama Xiang mini-pigs to explore the effects of different dietary β-hydroxy-β-methylbutyrate (HMB) levels (0, 0.13, 0.64 or 1.28%) on lipid metabolism of adipose tissue. Results showed that HMB decreased the fat percentage of pigs (linearly, < 0.05), and the lowest value was observed in the 0.13% HMB group. Moreover, the colonic acetic acid concentration and the relative abundance were increased in response to HMB supplementation ( < 0.05). Correlation analysis identified a positive correlation between the relative abundance and acetic acid production, and a negative correlation between fat percentage and the relative abundance or acetic acid production. HMB also upregulated the phosphorylation (p) of AMPKα, Sirt1, and FoxO1, and downregulated the p-mTOR expression. Collectively, these findings indicate that reduced fat percentage in Bama Xiang mini-pigs could be induced by HMB supplementation and the mechanism might be associated with the -acetic acid-AMPKα axis.
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| http://dx.doi.org/10.3389/fmicb.2021.736997 | DOI Listing |
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