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| http://dx.doi.org/10.3389/fnins.2021.746328 | DOI Listing |
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Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature.
Commun Biol
January 2025
Department of Physiology, New York Medical College, Valhalla, NY, USA.
Non-invasive, low intensity focused ultrasound is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported.
View Article and Find Full Text PDFRemotely induced electrical modulation of deep brain circuits in non-human primates.
Front Hum Neurosci
December 2024
Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States.
Article Synopsis
- A novel noninvasive method combines magnetic and focused ultrasonic fields to create electric fields deep in the brain for potential treatments of mental and neurological disorders.
- This study tested this method on non-human primates' visual circuits, examining the effects of different ultrasonic pulse frequencies on neural activity.
- Results showed that low-frequency stimulation (5 Hz) inhibited brain activity, while higher frequencies did not, indicating the importance of pulse frequency in neuromodulation without safety concerns.
Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer's disease pathology.
Alzheimers Res Ther
December 2024
Faculty of Health, Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.
Background: Although separate lines of research indicated a moderating role of sex in both sleep-wake disruption and in the interindividual vulnerability to Alzheimer's disease (AD)-related processes, the quantification of sex differences in the interplay between sleep-wake dysregulation and AD pathology remains critically overlooked. Here, we examined sex-specific associations between circadian rest-activity patterns and AD-related pathophysiological processes across the adult lifespan.
Methods: Ninety-two cognitively unimpaired adults (mean age = 59.
Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons.
Proc Natl Acad Sci U S A
December 2024
HHMI, Department of Neurobiology, Harvard Medical School, Boston, MA 02115.
Article Synopsis
- Gliomas are the most common malignant brain tumors, often leading to serious neurological issues and high mortality, yet they usually do not spread outside the brain, suggesting they depend on the brain's unique environment.* -
- This study used a special rabies virus tracing technique in a mouse model to identify neurons that connect with glioma cells, revealing various brain regions involved in glioma innervation.* -
- Molecular profiling showed that these connecting neurons (GINs) predominantly use glutamate and GABA neurotransmitters, and their electrophysiological properties differ from typical neurons, indicating a specific neural interaction that could influence glioma behavior.*
The therapeutic potential of low-intensity focused ultrasound for treating substance use disorder.
Front Psychiatry
November 2024
Department of Chemistry, University of Virginia, Charlottesville, VA, United States.
Substance use disorder (SUD) is a persistent public health issue that necessitates the exploration of novel therapeutic interventions. Low-intensity focused ultrasound (LIFU) is a promising modality for precise and invasive modulation of brain activity, capable of redefining the landscape of SUD treatment. The review overviews effective LIFU neuromodulatory parameters and molecular mechanisms, focusing on the modulation of reward pathways in key brain regions in animal and human models.
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