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* The analysis of 8,097 AD patients revealed that those with AD had a reduced risk for several cancers, with an overall hazard ratio of 0.822 for developing cancers.
* While lung cancer and prostate/testicular cancers showed a lower risk in AD patients, an increased risk of lymphoma was noted, indicating a complex relationship between AD and cancer.
Article Abstract
Introduction: We investigated the association between Alzheimer's disease (AD) and the risk of cancer in the Chinese population.
Methods: In this retrospective cohort study, multivariate Cox proportional hazard regression analysis was used to determine the correlation between AD and the risk of various cancers, as shown by hazard ratios (HRs) with 95% confidence intervals (CIs).
Results: Of 8097 AD patients, the HR for all subsequent cancers was 0.822 (95% CI, 0.728-0.928; P = .002). Among them, three specific cancers were associated with AD: lung cancer (HR, 0.656; 95% CI, 0.494- 0.871; P = .004), prostate and testicular cancer (HR, 0.414; 95% CI, 0.202-0.847; P = .016), and lymphoma (HR, 2.202; 95% CI, 1.005-4.826; P = .049).
Conclusion: Patients with AD might have a lower chance of developing several cancers, including lung cancer and prostate and testicular cancer. Meanwhile, a positive association between AD and a higher incident rate of lymphoma was observed.
