AI Article Synopsis
- The study investigated the prevalence and factors associated with newly developed depression in patients after craniotomy for brain tumor removal.
- Approximately 17.0% of the 4,275 patients studied were diagnosed with depression within one year post-surgery, with factors like age, rural living, and hospital stay length linked to higher depression rates.
- Newly acquired depression significantly increased the risk of two-year all-cause mortality, suggesting a need for monitoring mental health in these patients.
Article Abstract
Background: We aimed to investigate the prevalence and associated factors of newly developed depression in patients who underwent craniotomy for brain tumor removal, as well as its effect on long-term mortality.
Methods: Using a nationwide cohort database in South Korea, we included adult patients diagnosed with brain tumors who underwent craniotomy for brain tumor removal from January 1, 2011, to December 31, 2017. We excluded patients with a preoperative history of depression.
Results: Among 4,275 patients, 727 (17.0%) patients were newly diagnosed with depression within one year, postoperatively. Two-year all-cause mortality and mortality due to brain cancer occurred in 1,233 (28.8%) and 1,099 (25.7%) patients, respectively. In the multivariable logistic regression model, older age, living in rural areas, newly acquired brain disability, underlying other psychiatric disorders, and longer length of hospital stay were associated with a higher incidence of newly developed depression. In the multivariable Cox regression model, newly acquired depression was associated with a 1.58-fold higher 2-year all-cause mortality compared with that in other patients (hazard ratio: 1.58, 95% confidence interval: 1.38-1.80; P < 0.001).
Limitation: Lack of information regarding severity and pathologic tumor type.
Conclusion: Within one follow-up year, 17.0% of patients were newly diagnosed with depression after craniotomy for brain tumor removal. Some factors (old age, living in rural areas, newly acquired brain disability, longer length of hospital stay, and underlying other psychiatric illnesses) could be risk factors for newly diagnosed depression. Furthermore, newly developed depression was associated with an increased 2-year all-cause mortality.
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| http://dx.doi.org/10.1016/j.jad.2021.08.058 | DOI Listing |
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