Dynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation.

Biomed J

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung, Taiwan; Department of Respiratory Therapy, Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung, Taiwan; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Published: August 2022

AI Article Synopsis

  • Researchers investigated how changes in acute kidney injury (AKI) from day 1 to day 3 in sepsis patients could predict hospital mortality, focusing on patients in the ICU.
  • They analyzed data from 523 sepsis patients, categorizing them into normal, improved, and deteriorated AKI groups based on their AKI stages over the first three days.
  • Results indicated that patients whose AKI worsened had significantly higher mortality rates and abnormal inflammatory responses compared to those whose AKI remained stable or improved.

Article Abstract

Background: Sepsis-associated acute kidney injury (AKI) often worsens with the deterioration of a patient's condition. Therefore, we hypothesized that monitoring AKI dynamically from day 1 to day 3 was potential to predict hospital mortality. Specifically, we explored whether monitoring AKI dynamically in the intensive care unit (ICU) could be a sepsis phenotype predictive of mortality. A new classification was established based on the change in the AKI stage from admission day 1 and day 3. We compared the hospital mortality, cytokines, and immune response pattern between each group.

Methods: We retrospectively enrolled 523 patients with sepsis, and we calculated the AKI stages on day 1 and day 3 admission to ICUs. Among these 523 people, 388 of them were assigned to normal, improved, and deteriorated groups according to the changes in the AKI stages. 263 of which did not develop AKI on day 1 and day 3 (normal group). The AKI stage improved in 68 patients (improved group) and worsened in 57 (deteriorated group). We compared the mortality rates between the groups, and identified the relationship between the dynamic AKI status, immune response patterns, and cytokine levels.

Results: The hospital mortality rate in the deteriorated group was higher than that in the non-deteriorated group (combination of normal and improved group) (p = 0.004). Additionally, according to the Kaplan-Meier analysis, the non-deteriorated group had a distinct hospital survival curve (p = 0.004). Furthermore, both the overexpression of tumor necrosis factor-α and decreased monocyte expression of human leukocyte antigen-DR were present in the deteriorated group.

Conclusions: The deteriorated group was associated with a higher hospital mortality rate, potentially resulting from an abnormal inflammatory response. Worsening AKI in the first 3 days of ICU admission may be a sepsis phenotype predictive of hospital mortality.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486242PMC
http://dx.doi.org/10.1016/j.bj.2021.08.006DOI Listing

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