The current understanding on the clinical efficacy of Rho-associated protein kinase (ROCK) inhibitor for treating Fuchs endothelial corneal dystrophy is summarized to clarify whether the "off-label" ROCK-inhibitor eye-drop application are appropriate. ROCK-inhibitor eye drops may eventually be deemed a cutting-edge therapy for Fuchs endothelial corneal dystrophy patients with acute corneal endothelial defect.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423139PMC
http://dx.doi.org/10.1097/ICO.0000000000002642DOI Listing

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