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A potentially lifesaving error: unintentional high-dose adrenaline administration in anaphylaxis-induced cardiac arrest; a case report.
Int J Emerg Med
June 2024
University Emergency Department, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Background: Cardiopulmonary resuscitation is a crucial skill for emergency medical services. As high-risk-low-frequency events pose an immense mental load to providers, concepts of crew resource management, non-technical skills and the science of human errors are intended to prepare healthcare providers for high-pressure situations. However, medical errors occur, and organizations and institutions face the challenge of providing a blame-free error culture to achieve continuous improvement by avoiding similar errors in the future.
View Article and Find Full Text PDFHypersensitivity Reaction and Rapid Drug Desensitization with Chemotherapeutics: A Tertiary Reference Center Experiences.
Int Arch Allergy Immunol
September 2023
Department of Allergy and Immunology, Süreyyapasa Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Introduction: Chemotherapy drugs have been in our lives for a long time, and all agents have the potential to develop hypersensitivity. Rapid drug desensitization is an option when hypersensitivity develops. The aim of this study was to examine the characteristics, diagnostic processes, and treatment results of patients with chemotherapeutic agent hypersensitivity who applied to our tertiary reference center.
View Article and Find Full Text PDFPaclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions.
Cell Death Dis
May 2022
Dompé Farmaceutici SpA, Via Campo di Pile, 67100, L'Aquila, Italy.
Chemotherapy-induced peripheral neuropathy (CIPN) and hypersensitivity reactions (HSRs) are among the most frequent and impairing side effects of the antineoplastic agent paclitaxel. Here, we demonstrated that paclitaxel can bind and activate complement component 5a receptor 1 (C5aR1) and that this binding is crucial in the etiology of paclitaxel-induced CIPN and anaphylaxis. Starting from our previous data demonstrating the role of interleukin (IL)-8 in paclitaxel-induced neuronal toxicity, we searched for proteins that activate IL-8 expression and, by using the Exscalate platform for molecular docking simulations, we predicted the high affinity of C5aR1 with paclitaxel.
View Article and Find Full Text PDFSevere anaphylaxis caused by intravenous anti-cancer drugs.
Cancer Med
October 2021
Department of Pulmonology, Yokohama City University Hospital, Yokohama, Japan.
Article Synopsis
- The study looked at severe allergic reactions called anaphylaxis that can happen with chemotherapy drugs given through IV.
- Researchers studied the medical records of over 5,500 cancer patients from 2013 to 2020 and found 27 cases of severe anaphylaxis.
- The most common drug causing these reactions was carboplatin, and many patients had these severe reactions shortly after their treatment began.
Chemotherapy-induced anaphylaxis and fatal anaphylaxis in the United States: Incidence and risk factors.
Clin Exp Allergy
November 2021
Division of Pulmonary, Allergy, and Sleep Medicine, Mayo Clinic, Jacksonville, FL, USA.
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