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Vintages for New Fashion: Red-Shifted Photoswitching via the Triplet-Photoreaction Channel with Charge-Transfer Complex Sensitizers.
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Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China.
Triplet-sensitization has been proven invaluable for creating photoswitches operated over a full visible-light spectrum. While designing efficient triplet-sensitizers is crucial for establishing visible-light photochromism, it remains an appealing yet challenging task. In this work, we propose a versatile strategy to fabricate triplet-sensitizers with intermolecular charge-transfer complexes (CTCs).
View Article and Find Full Text PDFThe multifaceted role of the inferior colliculus in sensory prediction, reward processing, and decision-making.
Elife
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Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
The inferior colliculus (IC) has traditionally been regarded as an important relay in the auditory pathway, primarily involved in relaying auditory information from the brainstem to the thalamus. However, this study uncovers the multifaceted role of the IC in bridging auditory processing, sensory prediction, and reward prediction. Through extracellular recordings in monkeys engaged in a sound duration-based deviation detection task, we observed a 'climbing effect' in neuronal firing rates, indicative of an enhanced response over sound sequences linked to sensory prediction rather than reward anticipation.
View Article and Find Full Text PDFDistinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes.
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Waksman Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America.
Mitosis and meiosis have two mechanisms for regulating the accuracy of chromosome segregation: error correction and the spindle assembly checkpoint (SAC). We have investigated the function of several checkpoint proteins in meiosis I of Drosophila oocytes. Increased localization of several SAC proteins was found upon depolymerization of microtubules by colchicine.
View Article and Find Full Text PDFBacterial sensor evolved by decreasing complexity.
Proc Natl Acad Sci U S A
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Department of Biotechnology and Environmental Protection, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada 18008, Spain.
Bacterial receptors feed into multiple signal transduction pathways that regulate a variety of cellular processes including gene expression, second messenger levels, and motility. Receptors are typically activated by signal binding to ligand-binding domains (LBDs). Cache domains are omnipresent LBDs found in bacteria, archaea, and eukaryotes, including humans.
View Article and Find Full Text PDFDecreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans.
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Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
RNA interference (RNAi) mediates antiviral defense in many eukaryotes. Caenorhabditis elegans mutants that disable RNAi are more sensitive to viral infection. Many mutants that enhance RNAi have also been identified; these mutations may reveal genes that are normally down-regulated in antiviral defense.
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