AI Article Synopsis
- Perilipin-2, a protein that coats lipid droplets, has been linked to cancer progression but its role in hepatoblastoma (HB) is not well understood.
- Researchers analyzed 87 HB samples, using immunohistochemistry to examine perilipin-2 expression and its relationship with patient outcomes.
- The study found that perilipin-2 was more highly expressed in fetal HB compared to embryonal HB, with strong expression correlating to better event-free survival, suggesting it may serve as a positive prognostic marker in HB.
Article Abstract
Perilipin-2, a lipid droplet (LD) coating protein, has been found to be involved in cancer progression. However, its role in hepatoblastoma (HB) is undefined. We collected 87 HB samples and the corresponding clinical data. Immunohistochemistry (IHC) staining was performed to detect perilipin-2 and the association of the perilipin-2 expression with clinical characteristics and prognosis was analyzed. The expression of perilipin-2 was increased in fetal HB components in comparison to embryonal HB components. The predominant staining pattern was vesicular in fetal HB cells, while it was granular in embryonal HB cells. Furthermore, strong expression of perilipin-2 was associated with the histopathological type of fetal predominant HB. Although event-free survival (EFS) did not differ to a statistically significant extent between the strong and weak expression groups in a univariate survival analysis, a multivariate survival analysis revealed that EFS was significantly improved in the strong perilipin-2 expression group. In conclusion, perilipin-2 is differentially expressed in HB and the strong expression of perilipin-2 predicts a better prognosis.
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| http://dx.doi.org/10.14670/HH-18-371 | DOI Listing |
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