AI Article Synopsis
- The study explores how achieving a sustained virological response (SVR) from direct-acting antivirals (DAAs) affects recurrence and survival in patients with liver cancer related to hepatitis C after surgery.
- It compares outcomes of patients with postoperative DAA-induced SVR to those with preoperative SVR and a control group without DAA treatment.
- Results show that while DAA-induced SVR after surgery does not significantly affect disease-free survival, it can lead to improved liver function and higher overall survival rates compared to those who did not receive DAA treatment.
Article Abstract
Aim: We investigated effects of direct-acting antiviral (DAA)-induced sustained virological response (SVR) after liver resection in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) for postoperative recurrence and survival.
Methods: Surgical outcomes in 18 patients with postoperative DAA-induced SVR (HCC-DAA group) were compared with those in 23 patients with preoperative DAA-induced SVR (DAA-HCC group) and those in 10 patients who did not receive DAA therapy (control group). Patients who received DAA therapy >1 year after surgery and those with recurrence <1 year after surgery were excluded.
Results: Serum concentrations of aminotransferases improved 1 year after surgery in both the HCC-DAA and DAA-HCC groups. The number of HCC-DAA patients with albumin-bilirubin (ALBI) grade 1 increased from 11 to 15. The disease-free survival rate did not differ between HCC-DAA group (3 years, 60%) and the other two groups (DAA-HCC group, 92% and control group, 60%). The 3-year overall survival rates were better in the DAA-HCC group (84%) and HCC-DAA group (100%) than in the control group (46%; all ps < 0.05 according to Holm's test). Multivariable analysis revealed that tumor stage was an independent risk factor for postoperative recurrence, and ALBI grade at 1 year after surgery was predictive of postoperative survival, but DAA-induced SVR was neither.
Conclusions: Although postoperative DAA-induced SVR itself may not suppress postoperative recurrence, improvement in liver function as a result of DAA administration after surgery may prolong postoperative survival.
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| http://dx.doi.org/10.1111/hepr.13709 | DOI Listing |
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