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The Role of Inflammatory and Nutritional Indices in Postmenopausal Osteoporosis: A Retrospective Study.
J Clin Med
December 2024
Department of Obstetrics and Gynecology, Health Sciences University Etlik Zubeyde Hanim Maternity, Teaching and Research Hospital, 06010 Ankara, Turkey.
: Postmenopausal osteoporosis is characterized by impaired bone metabolism, inflammation, and nutritional deficiencies. This study aimed to evaluate the potential of inflammatory and nutritional markers in identifying decreased bone mineral density (BMD) in postmenopausal women. : This cross-sectional study retrospectively analyzed postmenopausal women from January 2018 and December 2023.
View Article and Find Full Text PDFTargeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer.
Mol Oncol
January 2025
Shanghai Stomatological Hospital & School of Stomatology & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Colorectal cancer (CRC) is a prevalent malignant tumor worldwide, with a high mortality rate due to its complex etiology and limited early screening techniques. This study aimed to identify potential biomarkers for early detection of CRC utilizing targeted metabolite profiling of platelet-rich plasma (PRP). Based on multiple reaction monitoring (MRM) mode, liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis identified metabolites in PRP collected from patients with CRC (n = 70) and healthy controls (n = 30).
View Article and Find Full Text PDFTrends and cost structure of drug-based secondary prevention of ischemic strokes.
Neurol Res Pract
January 2025
Goethe University Frankfurt, University Hospital, Department of Neurology, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.
Background: Advances in secondary stroke prevention, including direct oral anticoagulants (DOACs), dual antiplatelet therapies (DAPT), and cardiovascular risk management, have changed costs over the past decade. This study aimed to evaluate annual treatment costs and trends in drug-based secondary prophylaxis after ischemic strokes.
Methods: Annual treatment costs were evaluated using the net costs per defined daily dosage (DDD) of discharge medications for ischemic stroke patients treated in 2020 at the University Hospital Frankfurt, Germany.
Elevated Vitamin B12 Levels in Myeloproliferative Neoplasm (MPN) Patients: A Potential Diagnostic and Prognostic Marker.
J Blood Med
December 2024
Department of Hematology, Hamad Medical Corporation, Doha, Qatar.
Article Synopsis
- The study investigates the link between elevated vitamin B12 levels and myeloproliferative neoplasms (MPNs), which include types of blood cancers like CML, PV, MF, and ET, suggesting that higher B12 could indicate disease presence and activity.
- Data from 467 MPN patients showed that 20% had elevated B12 levels, particularly in those with CML, with significant reductions in B12 levels observed after one year of treatment.
- While increased B12 levels appear related to MPN activity, their effectiveness as a consistent diagnostic marker needs more research to establish reliable sensitivity, specificity, and cutoff values.
Investigating the effect of quail egg supplementation enriched with marine macroalgae on hematological indices, lipid profile parameters, and blood glucose level of Sprague Dawley rats during lactation and offspring growth.
Open Vet J
November 2024
Department of Animal Nutrition and Feed Science, Faculty of Animal Science, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background: The lactation period is a crucial period where the nutritional status and the mother's environment influence milk production, impacting organ differentiation, function, and structure in the baby's body.
Aim: The study aimed to determine the impact of providing lactating rats with quail egg supplements enriched with marine macroalgae on their physiological condition (blood cells, lipids, blood glucose, antioxidant activity, and prolactin hormone levels) and the growth of their offspring.
Methods: The study involved 25 lactating Sprague Dawley white rats aged 3 months old and weighing approximately 200 g divided into five treatment groups thus; T0 as the control, T1 with quail eggs enriched with commercial feed, T2 with quail eggs enriched with 3% of marine macroalgae, T3 with quail eggs enriched with 4% of marine macroalgae, and T4 with quail eggs enriched with 5% of marine macroalgae, which received one quail egg for 21 days.
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