AI Article Synopsis
- Malignant peripheral nerve sheath tumors (MPNSTs) vary in severity and can be mistaken for other nerve tumors based on their cellular appearance in histological analysis.
- A 57-year-old male patient presented with a recurrent tumor in the larynx, leading to a surgical evaluation that revealed both high-grade and low-grade MPNST lesions in the affected tissue.
- The study highlights the importance of detailed immunohistochemical examination in accurately diagnosing and treating these tumors to improve patient outcomes, especially in preserving vocal function.
Article Abstract
Malignant peripheral nerve sheath tumors (MPNSTs), as defined by immunohistochemical evaluation, are identified along a spectrum ranging from atypical neurofibroma to high-grade MPNST because these tumors are similar in terms of cell shape and tissue components on hematoxylin-eosin (HE) staining. The patient was a 57-year-old male referred to our hospital, with a recurrent red tumor at the anterior commissure of the larynx and submucosal swelling of the right vocal fold. A surgical specimen from a right horizontal partial laryngectomy was evaluated immunohistochemically. A high-grade MPNST lesion was included in the submucosal white tumor, whereas a low-grade MPNST lesion was encountered around the high-grade MPNST lesion. This tumor may involve different malignancies even when it is small. Although intra-tumor heterogeneity in cancers has been reported recently, careful immunohistochemical examination can be important and beneficial for eradicating the tumor while preserving vocal function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407030 | PMC |
| http://dx.doi.org/10.1093/jscr/rjab373 | DOI Listing |
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