AI Article Synopsis
- The study aimed to compare serum immunoglobulin E (IgE) and serotonin levels in patients with chronic suppurative otitis media (CSOM) undergoing different treatment regimens.
- Results indicated significant differences in IgE and serotonin levels among groups, with elevated IgE in untreated patients and lower serotonin across all CSOM groups compared to healthy controls.
- The conclusion suggested that while antibiotics can reduce IgE levels, they do not normalize serotonin levels, highlighting the need for monitoring and treating possible depression in CSOM patients.
Article Abstract
Objective: To determine the serum immunoglobulin E and serotonin levels of patients with chronic suppurative otitis media (CSOM) with and without treatment.
Methods: This is a case-control study carried out in ENT ward of Jinnah Postgraduate Medical Centre Karachi Pakistan from May to September 2018.. Sample (n=160) was divided into four groups (40 individuals per group) as G1: control negative (group-1 without any disease), G2: positive control (patients didn't received medicines), G3: group (patients treated with co-amoxicillin 1000mg per day) and G4: group (patients treated with ciprofloxacin1000mg per day). After treatment period of One week serum immunoglobulin E and serotonin concentrations were evaluated by Elisa method at 450nm.Statistical evaluation was carried out using one-way ANOVA (<0.05) followed by post hoc (tukey test) for further group comparison. In order to find out correlation between IgE and serotonin with CSOM Pearson's correlation was applied.
Results: There was no significant ( > 0.05) association found between genders with serotonin as well as with IgE levels in CSOM patients. One way ANOVA showed significant difference (<0.05) for IgE and serotonin levels and post hoc (tukey test) showed significant higher of IgE levels in CSOM patients of G2 positive control (diseased patients) was observed when compared to the control negative group (healthy individuals) and also from treated groups of G3 and G4. This also showed that serotonin levels were significantly low in G2 (positive control) as well as in treated groups of G3 and G4 in contrast with healthy individuals of group G1.
Conclusion: Antibiotics may revert the higher levels of IgE but cannot attenuate the decreased levels of neurotransmitter (serotonin) like healthy individuals, therefore, depression levels of CSOM patients should be monitored, scored and attenuated with proper intervention of antidepressants or counseling.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377913 | PMC |
| http://dx.doi.org/10.12669/pjms.37.5.2414 | DOI Listing |
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