AI Article Synopsis
- This study investigated the natural infection rate of sandflies and their associated parasites in two counties of Ilam province, Iran, known for cutaneous leishmaniasis.
- Researchers collected sandflies using sticky traps over a six-month period and identified the species using morphological and genetic methods, specifically focusing on their kDNA.
- The findings revealed a high genetic diversity among the parasite isolates, with six distinct clusters identified, suggesting a varied distribution of different clones in the studied area.
Article Abstract
This study aimed to screen the natural infection rate of in and in two counties (Mehran and Dehloran) of Ilam province as cutaneous leishmaniasis endemic areas in the west of Iran. Furthermore, the genetic diversity of parasite species that are isolated from vectors, was investigated. Sandflies were collected by sticky traps from May 2018 to October 2018. Afterward, specimens were prepared for species identification by morphological features. DNA was extracted from female sandflies, and minicircle kDNA was used to identify isolates through nested-PCR, followed by genetic diversity between isolates was investigated by sequence analysis of the amplified minicircle kDNA. Natural infection of the was shown in all positive specimens using nested-PCR. Analysis of data from 14 isolates displayed a high level of genetic diversity in . In the phylogenetic trees, all of the isolates occurred in six clusters. Clusters I, II, III, and VI contained isolated strains from While clusters IV and V contained isolated strains from . Genetic diversity of isolated from vectors was investigated in western Iran for the first time. According to the results of this study, probably "various clones of populations are distributed in the study area.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368947 | PMC |
| http://dx.doi.org/10.1007/s12639-021-01369-y | DOI Listing |
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