AI Article Synopsis
- The study investigates how common abnormal early cleavage (ACL) in embryos is, particularly using time-lapse imaging, and what patient or treatment factors might influence this occurrence.
- Data for the research was gathered from 318 IVF cycles at a single center between December 2015 and August 2017, focusing on diploid zygotes that cleaved on day 2, with a retrospective analysis of embryo videos to assess ACL.
- Results showed a significant prevalence of ACL in the observed embryos, with notable differences linked to the origin of the embryos, and specific conditions like endometriosis, but no IVF cycle-related factors were statistically tied to ACL occurrence.
Article Abstract
Research Question: What is the prevalence of embryo abnormal early cleavage (ACL) identified by time lapse and factors related to patients and treatment that explain ACL occurrence?
Design: A single-centre, retrospective cohort study. Data were collected on all IVF cycles for which embryos were observed in the EmbryoScope® between December 2015 and August 2017. Only diploid zygotes cleaved on day 2 were included. The study included 318 cycles (250 couples and 1343 embryos). Embryo videos were retrospectively analysed for ACL. The prevalence of each type of ACL was recorded. The influence of clinical factors (whether they were intrinsic to patients or specific to IVF treatment) on ACL occurrence was analysed in multivariate multilevel mixed-effect logistic regression analysis.
Results: A high prevalence of ACL was observed: 37.6% (505/1343) of embryos presented at least one ACL, 22.8% (306/1343) a trichotomous mitosis, 25.8% (347/1343) a rapid cleavage, 6.7% (90/1343) a cell fusion and two or more ACL (16.1%). Part of the variation (12-25%) in ACL occurrence could be explained by embryo origin. Trichotomous mitosis and two or more ACL phenotypes were less likely to occur in women with endometriosis or tubal pathology and tubal pathology alone, respectively. No factor related to IVF cycles was found to be statistically associated with ACL occurrence.
Conclusions: Our findings emphasize the importance of considering embryo origin when interpreting studies focusing on embryo characteristics and factors that could affect their quality. The present study is limited by a small sample size of known embryo implantations and monocentric criterion.
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| http://dx.doi.org/10.1016/j.rbmo.2021.06.010 | DOI Listing |
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