Gold nanoparticles are emerging as promising nanomaterials to create nanoscale therapeutic delivery systems. The aim of the study was to synthesis of highly monodisperse and stable gold nanoparticles functionalized with polyethyleneimine (PEI) and polyethylene glycol (PEG), multiparametric investigation of their neuronal toxicological effects and evaluation of the cellular/suborgan biodistribution. Gold nanoparticles (AuNP and AuNP) were synthesized and their surfaces were electrostatically modified by PEI and PEG. Dorsal root ganglion (DRG) sensory neurones were isolated from BALB/c mice. Cell viability, apoptosis and ROS production were evaluated in vitro. Cellular and suborgan biodisribution of the AuNPs were investigated using inductively coupled plasma mass spectrometry (ICP-MS) technique. PEI and PEG surface coating increased both biocompatibility and biodistribution of the AuNPs. ICP-MS measurements showed the presence of gold in liver, spleen, kidney, heart, blood and brain within a 30 days period. The size and surface chemistry of the AuNPs are important parameters for potential nanoteranostic applications in the future studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.msec.2021.112308 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Interfacial Properties of Gold and Cobalt Oxyhydroxide in Plasmon-Mediated Oxygen Evolution Reaction.
J Phys Chem C Nanomater Interfaces
January 2025
Department of Chemistry and Biochemistry, San Francisco State University, 1600 Holloway Ave., San Francisco, California 94132, United States.
Water electrolysis is a green method of storing electrical energy in the chemical bonds of high-energy hydrogen gas (H). However, the anodic oxygen evolution reaction (OER) requires a significant kinetic overpotential, limiting the electrolysis rate. Recently, plasmonic gold nanoparticles (Au NPs) have been introduced to improve charge transfer at the interface between the OER electrocatalysts and the electrolyte under light illumination.
View Article and Find Full Text PDFNanoparticles as Delivery Vehicles for Vaccines: The Use of Gold Nanoparticles.
Curr Pharm Biotechnol
January 2025
School of Public Health, Sechenov University, Moscow, Russia.
Since their inception, therapeutic or prophylactic vaccines have emerged as promising candidates for the prevention or treatment of infections and various diseases, including cancer and autoimmune disorders. In recent times, gold nanoparticles (GNPs) have acquired active roles in the field of vaccine development due to their intrinsic capacity to adjust and enhance the immune response. Due to their characteristics, GNPs can exert optimal effects as both delivery vehicles and adjuvants.
View Article and Find Full Text PDFHyaluronan-coated gold nanoshells for enhanced synergistic effect and immunogenic cell response of chemo-photothermal therapy on lung cancer.
Int J Biol Macromol
January 2025
Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 100, Taiwan; Department of Oncology, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address:
Lung cancer (LC) is the predominant cause of cancer-related fatalities globally, with the highest death rates in both genders, primarily attributed to smoking. The non-kinase transmembrane cell surface glycoprotein, CD44, enhances LC cell migration and invasion, leading to drug resistance and an unfavorable prognosis. This research formulated a cisplatin-loaded gold nanoshell (HCP@GNS) integrated with hyaluronan (HCP@GNS@HA) to enhance targeting capability and realize a synergistic effect of chemo-photothermal therapy (chemo-PTT) against LC.
View Article and Find Full Text PDFNanoparticle-based colorimetric assays for early and rapid screening of the oncogenic HPV variants 16 and 18.
Clin Chim Acta
January 2025
iÓMICAS Research Institute, Pontificia Universidad Javeriana, Calle 17 # 121B - 155, Cali, Valle del Cauca 760031, Colombia; Chemistry and Chemical Engineering Division, California Institute of Technology, Pasadena, CA 91125, United States. Electronic address:
Cervical cancer is predominantly caused by human papillomavirus (HPV), with oncogenic strains HPV 16 and 18 accounting for most cases worldwide. Prompt and precise identification of these high-risk HPV types is essential for enhancing patient outcomes as it enables timely intervention and management. However, the existing HPV detection techniques are time-consuming, expensive, and require highly skilled personnel.
View Article and Find Full Text PDFA green impedimetric aptasensor for non-invasive and high-selective detection of tramadol validated by molecular dynamic simulation.
Talanta
January 2025
Department of Chemistry Education, Farhangian University, P.O. Box 14665-889, Tehran, Iran. Electronic address:
Although the dosage controlling of tramadol (TRA) as a banned deadly drug in human biofluids is medicolegally important a biocompatible method for its high-selective detection with fewer false interferences has been scarcely reported. Herein, a new impedimetric aptasensor is introduced by utilizing the aptamer (Apt) sequence with high affinity to TRA for the first time to non-invasively measure it. An oriented nanolayer of Au nanoparticles (AuNPs) is easily formed on the surface by the electrodeposition technique to high-densely load the Apt and embed the novel aptasensing interface via a user-friendly methodology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!