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The epidemiology and unmet need of migraine in five european countries: results from the national health and wellness survey.
BMC Public Health
January 2025
Praxis Gendolla, Essen, Germany.
Background: Despite the high global prevalence, burden, and direct and indicated costs, migraines are often under-diagnosed and undertreated. Understanding the prevalence of migraine and unmet needs is crucial for improving diagnosis and treatment across Europe (EU) countries; however, real-world studies are limited.
Methods: This retrospective cross-sectional survey utilized weighted patient-reported data from the 2020 National Health and Wellness Survey (NHWS) in five EU (5EU) countries (France, Germany, United Kingdom [UK], Italy, and Spain).
Prevalence, Treatment, and Unmet Needs of Migraine in the Middle East: A Systematic Review.
Pain Ther
February 2025
Consultant Neurology, Head of Stroke Program, Rashid Hospital, Dubai Medical College, Dubai, United Arab Emirates.
Introduction: Migraine is a debilitating neurological disorder characterized by recurrent throbbing, moderate-to-severe headaches that disrupt daily chores, leisure, and social activities of patients, impacting their overall quality of life (QoL). Despite the high disease burden, there is a scarcity of data on migraines within the Middle East (ME) region. Thus, a systematic literature review (SLR) was conducted to examine epidemiological data, treatment patterns, QoL, and unmet needs regarding migraines in the ME region.
View Article and Find Full Text PDF[Interictal burden of migraine and its evaluations: a literature review].
Rinsho Shinkeigaku
December 2024
Eli Lilly Japan K.K.
We conducted a targeted literature review on patient burden during the interictal period of migraine. The results of the literature review revealed that: (1) migraine-associated burden persists into the interictal period and is not confined to the headache episodes themselves; (2) anxiety over the possible recurrence of headache episodes is a factor that reduces daily activities and quality of life (QOL); and (3) prophylactic treatment with calcitonin gene-related peptide (CGRP) antibody drugs may reduce the burden during the interictal period. From these findings, it is considered important in migraine treatment to identify the unmet needs of patients, including the burden during the interictal period, and to select an appropriate treatment method based on the burden experienced by individual patients.
View Article and Find Full Text PDFRelative frequency, characteristics, and disease burden of patients with migraine unsuitable for triptan treatment: A systematic literature review.
Headache
January 2025
Evidera, Bethesda, Maryland, USA.
Objective: This review was conducted to systematically identify evidence characterizing patients with migraine who are unsuitable for triptans.
Background: Triptans are not suitable as first-line treatment for all patients with migraine due to contraindications, lack of efficacy, and/or poor tolerability. However, there is debate about the frequency and characteristics of these patients and the burden they experience.
Outcomes, unmet needs, and challenges in the management of patients who withdraw from anti-CGRP monoclonal antibodies: A prospective cohort study.
Cephalalgia
November 2024
Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.
Background: The anti-calcitonin gene-related peptide (CGRP), or its receptor (CGRP/R) monoclonal antibodies (mAbs), offer targeted, effective, and tolerated drugs for migraine. However, about 25% of patients fail to achieve a clinically meaningful response, usually leading to discontinuation. These patients often have a lengthy migraine history and multiple prior preventive treatment failures, resulting in limited therapeutic options.
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