Inhibition of either glycosylation or the protein synthesis leads to sharp drop of hemagglutinating (HA) and neuraminidase (Nase) activities in Newcastle disease virus (NDV)-infected cells. The drop can be prevented by tosyl-lysyl-chloromethyl-ketone, an inhibitor of trypsin-like proteases, or D-galactonolactone, an inhibitor of glycosidases, if added together with cycloheximide. Tosyl-lysyl-chloromethyl-ketone when added alone increases the level of both the HA and Nase activities as compared with non-treated virus-infected cells. It has been suggested that the actual level of the HA and Nase activities in the virus-infected cells is a result of dynamic equilibrium between the synthesis and post-translational functional maturation of the hemagglutinin-neuraminidase (HN) molecules, on the one hand, and the protease and glycosidase-mediated functional inactivation, on the other.
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