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Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses. | LitMetric

AI Article Synopsis

  • This study investigates the link between psychosocial factors (like depression, anxiety, and social support) and the risk of developing various types of cancer, including breast and lung cancer.
  • It aims to explore how these psychosocial factors interact with traditional cancer risk factors (such as smoking and alcohol use) and whether health behaviors mediate this relationship.
  • The research utilizes a large dataset from 18 cohorts, involving over 617,000 participants, to provide a comprehensive analysis that addresses limitations in previous studies.

Article Abstract

Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.

Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2).

Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553309PMC
http://dx.doi.org/10.1002/brb3.2340DOI Listing

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