Multiple cylindrical interstitial laser ablations (CILAs) of porcine pancreas in and models.

Background: The therapeutic capacity of multiple cylindrical interstitial laser ablations (CILAs) of pancreatic tissue was evaluated with 1064 nm laser light in and porcine pancreatic models.

Methods: A diffusing applicator was sequentially employed to deliver 1064 nm laser light in a cylindrical distribution to ablate a large volume of pancreatic tissue. tissue was tested at various power levels (5, 7, and 10 W) under US imaging. An porcine model was used to evaluate the clinical feasibility of multiple CILAs on pancreatic tissue at 5 W laparotomy ( = 3).

Results: Multiple CILAs symmetrically ablated a range of tissue volumes (2.4-6.0 cm) at various power levels. Multiple CILAs warranted a therapeutic capacity of symmetrically ablating pancreatic tissue. Both and pancreatic tissues after multiple CILAs at 5 W confirmed the absence of or minimal thermal injury to the peripheral tissue and carbonization.

Conclusions: The current findings suggest that the collective thermal effects from multiple CILAs can help widely ablate pancreatic tissue with minimal thermal injury. Further studies will investigate the safety of the proposed CILA treatment as well as acute/chronic responses of pancreatic tissue for clinical translations.