AI Article Synopsis
- Cell polarity is crucial for epithelial cells and is primarily regulated by scaffold proteins, with the CRB (crumbs) complex being essential in this network.
- PATJ is a key component of the CRB complex, highly conserved through evolution, and is vital for embryonic development, cell polarity, and the creation of cellular barriers.
- Recent research highlights PATJ's role in stroke outcomes, examining its biological structure, functions, and genetic variations that contribute to poor recovery following ischemic stroke.
Article Abstract
Cell polarity is an intrinsic property of epithelial cells regulated by scaffold proteins. The CRB (crumbs) complex is known to play a predominant role in the dynamic cooperative network of polarity scaffold proteins. PATJ (PALS1-associated tight junction) is the core component in the CRB complex and has been highly conserved throughout evolution. PATJ is crucial to several important events in organisms' survival, including embryonic development, cell polarity, and barrier establishment. A recent study shows that PATJ plays an important role in functional outcomes of stroke. In this article, we elaborate on the biological structure and physiological functions of PATJ and explore the underlying mechanisms of genetic polymorphism that are associated with poor functional outcomes in ischemic stroke.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405222 | PMC |
| http://dx.doi.org/10.2147/NDT.S310764 | DOI Listing |
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