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Predictive Value of PERCIST for Locally Advanced Non-Small Cell Lung Cancer Treated with Preoperative Induction Therapy - A Multicenter Study in Japan.

Cancer Manag Res

July 2024

Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Background: Induction therapy followed by surgery is recommended as an alternative treatment strategy for locally advanced non-small cell lung cancer (NSCLC). Patients who achieve pathologic response after induction therapy have better outcomes than non-responders; therefore, therapeutic response must be evaluated. Recently, new approaches for monitoring therapeutic responses, which are based on F-Fluorodeoxyglucose positron emission tomography (FDG-PET), have been developed.

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Background: Patients undergoing gastrointestinal surgery often experience hypotension following general anesthesia induction due to insufficient volume. This study aimed to assess whether pre-rehydration guided by carotid corrected flow time (FTc) could mitigate post-induction hypotension induced by general anesthesia.

Methods: Patients undergoing resection of gastrointestinal tumors were assigned to either the conventional treatment group (Group C) or the fluid treatment group based on FTc (Group F).

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Background: Changes to the undergraduate medical curriculum now offer a greater focus on community-based teaching, communication skills and medical humanities. Unfortunately, this has been at the expense of surgical teaching. The senior house officer is usually the first port of call when a patient is being referred to a plastic surgery department.

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Article Synopsis
  • This study aimed to determine if ultrasound measurements of cervical artery blood flow changes during a simulated end-inspiratory occlusion test (sEIOT) can predict postinduction hypotension (PIH) in patients undergoing general anesthesia.
  • Researchers focused on hemodynamic parameters, specifically corrected flow time (ΔFTc) and peak blood flow velocity (ΔCDPV), before and after the sEIOT in patients having gastrointestinal tumor surgery.
  • The findings indicated that a ΔFTc value below -16.57% effectively predicts PIH with high sensitivity and moderate specificity, while ΔCDPV showed less predictive value.
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Background And Aims: Doppler waveform analysis of carotid artery has been found to predict fluid responsiveness in patients undergoing elective surgeries. We evaluated the role of carotid artery corrected flow time (FTc) and respiratory variation of blood flow peak velocity (ðV) in predicting post induction hypotension in patients undergoing emergency laparotomy for peritonitis.

Material And Methods: Adult patients ( = 60) with perforation peritonitis undergoing emergency laparotomy under general anesthesia (GA) were recruited in this prospective, observational study.

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