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Long-Term Evolution of the Adaptive NKG2C NK Cell Response to Cytomegalovirus Infection in Kidney Transplantation: An Insight on the Diversity of Host-Pathogen Interaction. | LitMetric

AI Article Synopsis

  • Human CMV infection is common in kidney transplant recipients, with pretransplant Ag-specific T cells and adaptive NKG2C NK cells linked to a lower infection rate post-transplant.
  • An analysis of a cohort of CMV KTR revealed that adaptive NKG2C NK cells, along with CD8 and TcRγδ T cells, showed increased proportions over time in patients who developed viremia.
  • The study suggests that while adaptive NKG2C NK cells contribute to controlling CMV replication alongside T cells, their specific role in this process remains unclear, particularly in patients without detectable viremia.

Article Abstract

Human CMV infection is frequent in kidney transplant recipients (KTR). Pretransplant Ag-specific T cells and adaptive NKG2C NK cells associate with reduced incidence of infection in CMV KTR. Expansions of adaptive NKG2C NK cells were reported in posttransplant CMV-infected KTR. To further explore this issue, NKG2C NK, CD8, and TcRγδ T cells were analyzed pretransplant and at different time points posttransplant for ≥24 mo in a cohort of CMV KTR ( = 112), stratified according to CMV viremia detection. In cryopreserved samples from a subgroup ( = 49), adaptive NKG2C NK cell markers and T cell subsets were compared after a longer follow-up (median, 56 mo), assessing the frequencies of CMV-specific T cells and viremia at the last time point. Increased proportions of NKG2C NK, CD8, and TcRγδ T cells were detected along posttransplant evolution in viremia(+) KTR. However, the individual magnitude and kinetics of the NKG2C NK response was variable and only exceptionally detected among viremia(-) KTR, presumably reflecting subclinical viral replication events. NKG2C expansions were independent of zygosity and associated with higher viral loads at diagnosis; no relation with other clinical parameters was perceived. Increased proportions of adaptive NKG2C NK cells (CD57, ILT2, FcεRIγ) were observed after resolution of viremia long-term posttransplant, coinciding with increased CD8 and Vδ2 γδ T cells; at that stage CMV-specific T cells were comparable to viremia(-) cases. These data suggest that adaptive NKG2C NK cells participate with T cells to restore CMV replication control, although their relative contribution cannot be discerned.

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Source
http://dx.doi.org/10.4049/jimmunol.2100055DOI Listing

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