This study investigated the influences of lexical characteristics and talker accent on English spoken word recognition by first-language (L1) Korean second-language (L2) speakers of English. Stimuli were words that varied in phonological neighborhood density (PND) and word frequency (WF), produced by a L1 English speaker (L1 talker) and a L1 Korean speaker (L2 talker). Participants were 60 listeners from three groups: 20 L1 English speakers, 20 Korean L2 English speakers studying in the United States, and 20 Korean L2 English speakers studying in Korea. The 40 L2 English speakers varied widely in their estimated English proficiency. The results showed significant main effects of talkers, PND, and listener proficiency on word-recognition accuracy as well as significant interactions among stimulus talker (i.e., L1 vs L2 talker), PND, and WF and between stimulus talker and listener groups. However, we did not find that PND differentially affects word recognition in L2 learners, as had been found previously by Imai et al. [(2005). J. Acoust. Soc. Am. 117, 896-907] using the same design. Instead, our results paralleled closely those of Yoneyama and Munson [(2017). J. Acoust. Soc. Am. 141, 1308-1320], who examined L2 English speakers whose L1 was Japanese. These findings are discussed in light of the influence of L1 lexical structure on L2 phonological processing.
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Sci Rep
December 2024
Medical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Immune checkpoint inhibitor (ICI) treatment has proven successful for advanced melanoma, but is associated with potentially severe toxicity and high costs. Accurate biomarkers for response are lacking. The present work is the first to investigate the value of deep learning on CT imaging of metastatic lesions for predicting ICI treatment outcomes in advanced melanoma.
View Article and Find Full Text PDFNat Commun
December 2024
Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Pathogenic activating mutations in the fibroblast growth factor receptor 3 (FGFR3) drive disease maintenance and progression in urothelial cancer. 10-15% of muscle-invasive and metastatic urothelial cancer (MIBC/mUC) are FGFR3-mutant. Selective targeting of FGFR3 hotspot mutations with tyrosine kinase inhibitors (e.
View Article and Find Full Text PDFHere we report results of a phase 1 multi-institutional, open-label, dose-escalation trial (NCT02744287) of BPX-601, an investigational autologous PSCA-directed GoCAR-T® cell product containing an inducible MyD88/CD40 ON-switch responsive to the activating dimerizer rimiducid, in patients with metastatic pancreatic (mPDAC) or castration-resistant prostate cancer (mCRPC). Primary objectives were to evaluate safety and tolerability and determine the recommended phase 2 dose/schedule (RP2D). Secondary objectives included the assessment of efficacy and characterization of the pharmacokinetics of rimiducid.
View Article and Find Full Text PDFGuidelines recommend risk stratification of pulmonary arterial hypertension (PAH) patients to guide management. There are currently several risk stratification scores available, which have largely been validated in various pulmonary hypertension registries in the West but not in Asia. We aim to study the performance of these different risk scores in PAH patients from a multi-ethnic Asian population.
View Article and Find Full Text PDFLancet Reg Health Eur
February 2025
Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Background: Frailty is a significant predictor for adverse outcomes. Yet, data on prevalence and treatment of frail patients with acute coronary syndrome (ACS) remains limited. We aimed to investigate frailty prevalence, interventional treatment frequency, and in-hospital outcome for all patients hospitalized for ACS in Germany from 2005 to 2022 and validate the Hospital Frailty Risk Score (HFRS) in this population.
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