AI Article Synopsis
- - The study introduces a new method for creating benzo[]phosphole oxides by using a reaction that combines alkynylphosphine oxides with common cycloalkanes, alcohols, and ethers.
- - This process utilizes visible light and is environmentally friendly, operating without a photocatalyst and at room temperature.
- - The reaction is mild and doesn't require metals or bases, allowing for the efficient construction of diverse chemical structures through sequential C-H functionalization.
Article Abstract
We developed the radical cyclization/addition of alkynylphosphine oxides with easily available cycloalkanes, alcohols, and ethers using a visible-light and environmentally friendly synthetic strategy in the absence of photocatalyst at room temperature. This mild and metal- and base-free reaction provided a structurally varied set of significant benzo[]phosphole oxides through sequential C-H functionalization in an atom-economical manner.
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| http://dx.doi.org/10.1021/acs.joc.1c00841 | DOI Listing |
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